CT of the Middiaphyseal Femur: Cortical Bone Mineral Density and Relation to Porosity

Bousson, V.; Bergot, C.; Meunier, Alain; Barbot, Frédérique; Parlier‐Cuau, Caroline; Laval-Jeantet, A. M.; Laredo, Jean‐Denis

doi:10.1148/radiology.217.1.r00se11179

Cited by 116 publications

(87 citation statements)

References 42 publications

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“…Gatti and colleagues, (23) however, included more severe phenotypes, which may explain the difference of our findings. We expected patients with type I OI to have increased cortical porosity compared with controls due to increased bone turnover, (25,26) but were unable to show a significant difference between the groups. This may be due to lack of statistical power or to the fact that HR-pQCT cannot capture cortical pores that are smaller than the image resolution of 82 mm.…”

Section: Discussionmentioning

confidence: 86%

Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT

Folkestad

Hald

Hansen

et al. 2012

Journal of Bone and Mineral Research

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Osteogenesis imperfecta (OI) is a hereditary disorder characterized by decreased biosynthesis or impaired morphology of type I collagen that leads to decreased bone mass and increased bone fragility. We hypothesized that patients with OI have altered bone microstructure and bone geometry. In this cross-sectional study we compared patients with type I OI to age-and gender-matched healthy controls. A total of 39 (13 men and 26 women) patients with OI, aged 53 (range, 21-77) years, and 39 controls, aged 53 (range, 21-77) years, were included in the study. Twenty-seven of the patients had been treated with bisphosphonates. High-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia and dual-energy X-ray absorptiometry of total hip, femoral neck, trochanteric region, and the lumbar spine (L1-L4) were performed. The patients were shorter than the controls (159 AE 10 cm versus 170 AE 9 cm, p < 0.001), but had similar body weight. In OI, areal bone mineral density (aBMD) was 8% lower at the hip (p < 0.05) and 13% lower at the spine (p < 0.001) compared with controls. The trabecular volumetric bone mineral density (vBMD) was 28% lower in radius (p < 0.001) and 38% lower in tibia (p < 0.001) in OI compared with controls. At radius, total bone area was 5% lower in OI than in controls (p < 0.05). In the tibia, cortical bone area was 18% lower in OI (p < 0.001). In both radius and tibia the number of trabeculae was lower in patients compared to the controls (35% and 38%, respectively, p < 0.001 at both sites). Furthermore, trabecular spacing was 55% higher in OI in both tibia and radius (p < 0.001 at both sites) when compared with controls. We conclude that patients with type I OI have lower aBMD, vBMD, bone area, and trabecular number when compared with healthy age-and gender-matched controls. ß

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Section: Discussionmentioning

confidence: 86%

Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT

Folkestad

Hald

Hansen

et al. 2012

Journal of Bone and Mineral Research

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“…Therefore, quantification of bone water is of considerable interest. Further, it may provide a means of measuring pore volume fraction, which has been shown to increase with age (38). Furthermore, increased porosity impairs the mechanical competence of bone and thus increases the risk of hip fracture, as has been shown histologically (39).…”

Section: Discussionmentioning

confidence: 99%

In vivo MRI of submillisecond T₂ species with two‐dimensional and three‐dimensional radial sequences and applications to the measurement of cortical bone water

2007

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Water in dense collagenous tissues such as tendons and ligaments, as well as water in cortical bone that occupies the spaces of the lacuno-canicular system or is tightly bound to collagen, is not ordinarily detectable by MRI. Water proton T(2) in these structures is generally less than 1 ms. Recent advances in instrumentation in conjunction with non-Cartesian imaging strategies now allow center of k-space to be scanned 100 micros or less after excitation. We examined the performance of two radial pulse sequences, a 2D sequence with half-pulse excitation and a new 3D hybrid sequence with variable-echo Cartesian encoding in the third dimension, on a whole-body 3 T scanner. Both pulse sequences used long-T(2) soft-tissue suppression pulses. The half-pulse slice profiles observed experimentally agreed well with those computed on the basis of a numerical solution of Bloch equations. The techniques yielded a signal-to-noise ratio of the order of 25 in 9 min scan time at a nominal voxel size of 0.58 x 0.58 x 8 mm(3) and 50-90 micros 'echo time' in the cortex of the tibial mid-shaft. With the use of an external reference, the water volume fraction of cortical bone in four subjects (mean +/- SD age 32.25 +/- 5.3 years) was found to be 22.5 +/- 2.7%, in good agreement with literature values.

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“…Ayrıca, Martins ve arkadaşlarının Ti-Nb alaşımlarını geleneksel toz metalürjisi yöntemiyle ürettikleri çalışmada, 1500 °C sinterleme sonucunda %99.73 relatif yoğunluk elde etmişlerdir [12]. Numunelerde elde edilen porozite değerleri insan kortikal kemiği ile uyumludur (% 1-16) ancak literatürde [13], [14] . yaş ilerledikçe kortikal kemiğinin porozite miktarının artacağı rapor edilmiştir.…”

Section: Yoğunluk Ve Porozite Oranıunclassified

Effect of Nb addition on microstructural and mechanical properties of Ti-Nb based alloys produced by powder metallurgy

Yılmaz¹,

Gökçe²,

Fındık³

et al. 2017

Pamukkale J Eng Sci

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CT of the Middiaphyseal Femur: Cortical Bone Mineral Density and Relation to Porosity

Abstract: CT is effective in the measurement of age- and site-related changes in cBMD. Decreases in cBMD are closely correlated with increased cortical porosity.

Cited by 116 publications

References 42 publications

Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT

Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT

In vivo MRI of submillisecond T₂ species with two‐dimensional and three‐dimensional radial sequences and applications to the measurement of cortical bone water

Effect of Nb addition on microstructural and mechanical properties of Ti-Nb based alloys produced by powder metallurgy

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CT of the Middiaphyseal Femur: Cortical Bone Mineral Density and Relation to Porosity

Abstract: CT is effective in the measurement of age- and site-related changes in cBMD. Decreases in cBMD are closely correlated with increased cortical porosity.

Cited by 116 publications

References 42 publications

Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT

Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT

In vivo MRI of submillisecond T2 species with two‐dimensional and three‐dimensional radial sequences and applications to the measurement of cortical bone water

Effect of Nb addition on microstructural and mechanical properties of Ti-Nb based alloys produced by powder metallurgy

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In vivo MRI of submillisecond T₂ species with two‐dimensional and three‐dimensional radial sequences and applications to the measurement of cortical bone water