CT planning of boost irradiation in radiotherapy of breast cancer after conservative surgery

Change in Seroma Volume During Whole-Breast Radiation Therapy

“…Several reviews have shown that approximately 10-67% of scar-based boost plans were inaccurate in defining the boost volume when compared with surgical clip-based plans and result in geographical misses and breast tissue beyond the tumor bed being unnecessarily irradiated (6)(7)(8)(9). Moreover, two reviews have shown that scar-based plans result in geographical misses or modifications required in 70-80% of the cases when compared with CT-based plans (10,11). Benda et al reported that only 51% of the scar-based plans received 90% or more of the prescribed dose when compared with CT-generated boost plans (12).…”

Planning the Breast Boost: Comparison of Three Techniques and Evolution of Tumor Bed During Treatment

“…More recently, techniques using computed tomography (CT)-based three-dimensional planning have been used. Several publications have now called into question the accuracy of using clinical techniques, citing high rates of inadequate tumor bed coverage (3)(4)(5)(6)(7)(8). Most of these reports have focused on using the lumpectomy scar, with or without limited clinical information, to determine the clinical setup.…”

Virtual Simulation of a Boost Field in Adjuvant Radiotherapy of the Breast

“…Techniques using a CT and tumor bed clips for target volume definition have been published before as part of a three-dimensional planning procedure, which proved to be advantageous over a clinically guided conventional simulation [2,9,14]. Clinically guided treatment planning led to an underdosage of the tumor bed as well as to an unnecessary irradiation of breast tissue.…”