2023
DOI: 10.1038/s41698-023-00404-w
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CT radiomic signature predicts survival and chemotherapy benefit in stage I and II HPV-associated oropharyngeal carcinoma

Abstract: Chemoradiation is a common therapeutic regimen for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). However, not all patients benefit from chemotherapy, especially patients with low-risk characteristics. We aim to develop and validate a prognostic and predictive radiomic image signature (pRiS) to inform survival and chemotherapy benefit using computed tomography (CT) scans from 491 stage I and II HPV-associated OPSCC, which were divided into three cohorts D1–D3. The prognost… Show more

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“…Further work on chemotherapy sensitivity 19 and balancing toxicity with tumor control 20 could also inform future iterations of these trials, most of which include cisplatin as a radiosensitizer. 21 In conclusion, we demonstrate that GARD outperforms the NRG clinical nomogram of outcome as a prognostic biomarker in HPV+ OPSCC patients and defines prognostic groups that can inform clinical trial design. While HPV is a classic biomarker in that its result is fixed and cannot be changed, the GARD value for a patient can be optimized by adjusting the RT dose.…”
Section: Discussionmentioning
confidence: 67%
“…Further work on chemotherapy sensitivity 19 and balancing toxicity with tumor control 20 could also inform future iterations of these trials, most of which include cisplatin as a radiosensitizer. 21 In conclusion, we demonstrate that GARD outperforms the NRG clinical nomogram of outcome as a prognostic biomarker in HPV+ OPSCC patients and defines prognostic groups that can inform clinical trial design. While HPV is a classic biomarker in that its result is fixed and cannot be changed, the GARD value for a patient can be optimized by adjusting the RT dose.…”
Section: Discussionmentioning
confidence: 67%