CT volumetry of normal pancreas: correlation with the pancreatic diameters measurable by the cross-sectional imaging, and relationship with the gender, age, and body constitution

Abstract

Marked individual variations in normal pancreas volume were observed. Pancreatic volume could be computed using the diameters measurable by the cross-sectional imaging employing the formula: V = (AP(tail) + AP(body))/2 × L(body&tail) × CC(body) + (AP(head)/2)2 × 3.14 × CC(head).

Functional and morphological evolution of remnant pancreas after resection for pancreatic adenocarcinoma

“…Pancreatic adenocarcinoma is frequently accompanied by atrophy and duct dilatation distal to the tumor, [26] and duct obstruction can interfere with pancreatic endocrine function and can cause DM. [12,14] There are reports that preoperative DM improved after PD in some patients, [10,12,30] supporting our data that the acute pancreatic duct dilatation caused by obstruction by pancreatic cancer is reversible. Another mechanical change that accompanies is the removal of tumor mass, which can secrete diabetogenic agent.…”

“…[29] At 7 days postoperatively, when most patients resumed oral intake, indulged in active exercise, and systemic inflammation was under control, GTI decreased significantly, and subsequently remained stable. The favorable GTI profile after the immediate postoperative period was observed mainly in the PD group, presumably because more pancreas parenchyma is preserved after PD [14] and more a-cells remain. [10] However, these explanations inadequately explain why GTI improved versus preoperative values after pancreatic resection, which inevitably involves loss of pancreatic volume.…”

“…Our method tended to underestimate actual pancreas volumes, but calculated dimensions were comparable to previous reports, [20,25] except pancreas body length, which was shorter because we measured the length perpendicular to the resection plane. [14] Recently, Yoo et al [9] reported the evolution of RPV during the 12 months following PD in patients with diverse periampullary tumors, and compared RPVs between patients after external and internal drainage. Although they did not mention the degree of pancreatic duct dilatation, their results showed that after PD, RPV values decreased progressively with time presumably due to pancreatic atrophy.…”

“…[20] However, the procedure is time-consuming and requires additional software. [12] Djuric-Stefanovic et al [14] proposed a simpler method for measuring the pancreatic volume by treating the pancreatic head as a column and the body and tail as a square pillar. In the present study, we likened the pancreatic head to an ellipsoid and the body and the tail to a cylinder.…”

“…We tried to devise a new index for pancreatic endocrine functional assessment and evaluated morphological changes of remnant pancreas by approximating it to simple geometric solid figures in accord with appearances on abdominal computed tomography (CT) images. [14] The correlations between these parameters and their evolutions after surgical resection were analyzed and the implications were sought.…”