CTAB–tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] interaction: a tool for predicting organotin(IV) complex–cell membrane interaction parameters

Shah, Farooq Ali; Khan, Asad Muhammad; Sabir, Shaista; Ali, Saqib

doi:10.1007/s00396-015-3738-x

Cited by 10 publications

(2 citation statements)

References 22 publications

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“…This reduction in activity of complex reveals stronger interaction with micelles and this phenomenon is particularly very useful for prolonged delivery of pharmaceutical agents in biological systems. So CMC regulates release rate of drug in biological system [25] (see Figs. 8 and 9).…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and characterization of cationic surfactants and their interactions with drug and metal complexes

Akhter

Ullah

Talat

et al. 2019

Heliyon

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Two new cationic surfactants, n-hexadecyl-3-methylpyridinium bromide and n-heptadecyl-3-methylpyridinium bromide have been synthesized and characterized in solid state by FT-IR, and in solution by 1 H- and 13 C-NMR spectroscopy. The values of critical micelle concentration (CMC) were determined by UV-visible spectroscopy and conductometry. Interaction of synthesized surfactants with two anionic drugs, i.e., diclofenac sodium {[2-(2, 6-Dichloroanilino) phenyl] acetic acid} and ketoprofen [(RS)-2-(3-benzoylphenyl) propionic acid] was studied by UV-visible spectroscopy. Binding constant (K), Gibb's free energy (ΔG) and number of drug molecules (n) per micelle were also calculated. These synthesized surfactants were proved to be efficient in increasing the solubility and bioavailability of drug molecules. In order to check the carrier efficiency of synthesized surfactants against bioactive coordinate, on complexes, interaction of recently reported bioactive zinc complexes was tested with synthesized cationic surfactants by conductometric measurements. Mole fractions (X cmc ) and Gibbs free energy (ΔG cmc ) values were also calculated. Both surfactants were further screened for anti-fungal and anti-bacterial activities.

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Section: Resultsmentioning

confidence: 99%

“…To calculate the ΔG m values of complex surfactant interactions, following expressions was used [25, 26]. …”

Section: Resultsmentioning

confidence: 99%