CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice
Hiroe Tetsu,
Kanako Nakayama,
Taku Nishijo
et al.
Abstract:Atopic dermatitis (AD) patients with skin barrier dysfunction are considered to be at a higher risk of allergic contact dermatitis (ACD), although previous studies showed that attenuated ACD responses to strong sensitizers in AD patients compared to healthy controls. However, the mechanisms of ACD response attenuation in AD patients are unclear. Therefore, using the contact hypersensitivity (CHS) mouse model, this study explored the differences in CHS responses to hapten sensitization between NC/Nga mice with … Show more
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