CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients

Meyer, Ivo; Wintermark, Max; Demonet, Jean-François; Michel, Patrik

doi:10.3174/ajnr.a4370

Cited by 6 publications

(2 citation statements)

References 14 publications

(17 reference statements)

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“…Our research group already studied hypoperfusion characteristics in patients with TIA who underwent PCT, 15 and we previously demonstrated that they might be useful in differential diagnosis from other conditions, including transient global amnesia or posterior reversible encephalopathy syndrome. 16 , 17 Similarly, in the present study, we suggest that a CTP-quantitative analysis might detect a moderate hypoperfusion pattern in the cerebral regions during MA, compatible with aura symptoms, which could help in distinguishing from TIA.…”

Section: Discussionsupporting

confidence: 77%

Computed tomographic perfusion abnormalities in acute migraine with aura: Characteristics and comparison with transient ischemic attack

Strambo

Nannoni

Rebordão

et al. 2022

European Stroke Journal

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Introduction: Migraine with aura (MA) accounts for up to 10% of “stroke mimics” and can present cerebral perfusion abnormalities. We aimed to compare perfusion-CT (PCT) findings in acute-onset MA mimicking an ischemic stroke with those observed in transient ischemic attack (TIA). Methods: We retrospectively studied patients admitted to our hospital between 2002 and 2014 with suspicion of acute ischemic stroke, having PCT and receiving a final diagnosis of MA. We visually assessed PCT for the presence and extent of focal hypoperfusion (FHP). MA patients with FHP were compared with consecutive TIA patients showing FHP. We performed both qualitative and quantitative analysis of PCT. Results: Of 47 patients with MA (median age = 33 years, 55% females), 16 (34%) displayed FHP. Compared to MA patients without FHP, MA patients with FHP had similar headaches and aura features, but a less frequent history of MA ( p = 0.010). Compared to 74 TIA patients with FHP (median age = 69 years, 43% females), MA patients with FHP showed hypoperfusion that more frequently involved adjacent vascular territories or a whole hemisphere ( p < 0.001). In addition, hypoperfusion in MA patients had a less pronounced increase in rMTT (1.2 vs 1.8, p < 0.001) and rTTP (1.1 vs 1.2, p < 0.001), and a lesser decrease in rCBF (0.8 vs 0.6, p < 0.001) compared to hypoperfusion in TIA. rMTT displayed the best discriminative ability to differentiate MA from TIA. Conclusion: Focal perfusion abnormalities in acute MA often involve adjacent vascular territories and hypoperfusion is less pronounced than in TIA. MA can be best differentiated from TIA by a smaller rMTT increase.

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Section: Discussionsupporting

confidence: 77%

Computed tomographic perfusion abnormalities in acute migraine with aura: Characteristics and comparison with transient ischemic attack

Strambo

Nannoni

Rebordão

et al. 2022

European Stroke Journal

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“…Retrograde amnesia refers to forget past events, and new memories can be formed. TGA refers to sudden anterograde amnesia with or without retrograde amnesia, lasting less than 24 hours, without other clinical neurological dysfunction (1,2). The current diagnosis of TGA mainly refers to the standard established by Hodges et al (3), including confirmed by witnesses; anterograde memory loss; clear consciousness; no other cognitive impairments except for memory impairment; complete insight; no positive signs on neurological physical examination, and no recent history of brain trauma and seizures.…”

Section: Discussionmentioning

confidence: 99%

Transient global amnesia after radiofrequency catheter ablation of supraventricular tachycardia: a case report

Sun¹,

Huang²,

Chen³

et al. 2021

Cardiovasc Diagn Ther

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Transient global amnesia (TGA) is a neurological disorder characterized by sudden onset of anterograde amnesia with or without retrograde amnesia, lasting less than 24 hours, without other clinical neurological dysfunction. TGA with short duration and benign prognosis is usually neglected in clinical practice. Transient total amnesia after radiofrequency ablation is rare and its etiology is unknown. We report a case of 27-year-old man who experienced TGA after radiofrequency catheter ablation of supraventricular tachycardia. The patient had no other cognitive and motor impairment except for memory impairment. The symptom lasted for about six hours and relieved without recurrence. Nervous system examination showed that 12 pairs of cranial nerves were normal, the muscle strength and muscle tone of the limbs were normal, physiological reflexes existed, and no pathological reflexes were elicited. Tests were performed immediately and normally including blood routine examination, liver and kidney function, electrolyte, blood glucose, thyroid function, blood coagulation function, D-dimer, myocardial injury markers, blood gas analysis and other hematological. There is no abnormality in electrocardiogram (ECG), chest X-ray, cervical vascular ultrasound, and cardiac color Doppler ultrasound examination. Head magnetic resonance examination magnetic resonance imaging (MRI) showed dots in right frontal lobe and bilateral ventricles in T2-weighted images. There was no cerebral infarction and cerebral hemorrhage. The patient received low flow oxygen inhalation and aspirin 300mg orally. The outcome of patient with TGA is benign. There are still many unsolved mysteries worthy of long-term follow-up.

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Investigation of TGA (2): Neuroimaging

Larner

2022

Transient Global Amnesia

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CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients

Abstract: BACKGROUND AND PURPOSE:Medial temporal lobe abnormalities on DWI and functional imaging are occasionally observed in patients with transient global amnesia. We used CTP to study these patients during or briefly after resolution of their amnesic syndrome.

Cited by 6 publications

References 14 publications

Computed tomographic perfusion abnormalities in acute migraine with aura: Characteristics and comparison with transient ischemic attack

Computed tomographic perfusion abnormalities in acute migraine with aura: Characteristics and comparison with transient ischemic attack

Transient global amnesia after radiofrequency catheter ablation of supraventricular tachycardia: a case report

Investigation of TGA (2): Neuroimaging

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