Cu(II)‐Catalyzed Synthesis of 2,3,6‐Trisubstituted Pyridines from Saturated Ketone and Alkynones/1,3‐Dicarbonyl Compounds

Abstract

In this work, a highly efficient one-pot synthesis of 2,3,6trisubstituted pyridines has been achieved through coppercatalyzed saturated ketones and alkynones/1,3-dicarbonyl compounds. This method provided the convenient routes to the synthesis of 2,3,6-trisubstituted pyridines with good functional group tolerance. Compared with previous works, this method does not require the synthesis of enamine in advance.

Transition metal-free [3 + 3] annulation of cyclopropanols with β-enamine esters to assemble nicotinate derivatives

“…4 f Herein, many methods have been developed for constructing nicotinate scaffolds and the representative approaches include the condensation of carbonyl compounds with ammonia, transition metal catalysis, ring expansion of azirines, C–H functionalization and cycloaddition reactions. 5 Despite this progress, a sustainable, practical and metal-free strategy for the synthesis of nicotinate derivatives is still desired and challenging.…”