Cu(II) complexes with a sulfonamide derived from benzoguanamine. Oxidative cleavage of DNA in the presence of H2O2 and ascorbate

DNA interaction of new copper(II) complexes with sulfonamides as ligands

“…The sulfonamides Hqmesa, Hqtbsa, and Haqtsa were prepared by reacting 8-aminoquinolein with 2-mesitylenesulfonyl, 4-tert-butylbenzenesulfonyl, or a-toluenesulfonyl chlorides, respectively, in accordance with the method described elsewhere [27,31]. Elemental chemical analysis data are in agreement with the formulae C 18 The copper complexes were obtained through a direct reaction of the sulfonamides with copper salts.…”

“…We have previously reported [25][26][27][28][29][30][31][32] on the synthesis and characterization of several Cu(II) complexes with sulfonamide ligands, as well as on mixed complexes with other ligands; indeed, some of these complexes have been found to have an outstanding nuclease activity. In light of our research, we have concluded that the precise nature of the ligands is of paramount importance in the interaction of the complex with the DNA molecule.…”

Synthesis, X‐ray Crystal Structures, DNA Binding and Nuclease Activities of Two Novel 1,2,4‐Triazole‐Based CuII Complexes

“…This phenomenon could be seen in the reported documents. [5,40] Smearing was found for both complexes under the H 2 O 2 /ascorbate condition (lane 6 and 12, Figure 1S), whereas it could not be seen under the ascorbate condition ( Figure 2S). The results indicate the following increasing order of efficiency: ascorbate Ͻ H 2 O 2 Ͻ H 2 O 2 / ascorbate.…”

Mn(II) complexes with sulfonamides as ligands.

“…Among copper complexes explored so far, the copper complexes of 1,10-phenanthroline and their derivatives attract great attentions due to their high nucleolytic efficiency, which are able to break the DNA strand [17][18][19]. We have previously reported the synthesis and characterization of a large number of copper complexes with sulfonamides, as well as their DNA interaction [20][21][22][23][24][25][26][27][28].…”