Cu II -Na I heteronuclear complex as anticancer entity against human breast cancer cell lines: DNA binding, cleavage, and Computational studies

Usman, Mohammad; Tabassum, Sartaj; Arjmand, Farukh; Khan, Rais Ahmad; Ali, Mushir; Al‐Lohedan, Hamad A.; Alsalme, Ali; Farah, Mohammad Abul; Al-Anazi, Khalid Mashay; Ahmad, Musheer

doi:10.1016/j.ica.2018.04.036

Cited by 17 publications

(11 citation statements)

References 47 publications

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“…However, the band at 325 nm (C=N–chromophore absorption) shows hypochromism of 28% and 25% revealed the partial intercalation behavior of complexes 1 and 2 , respectively. Moreover, the more pronounced hyperchromic effect along with blue shift allude that both complexes bind through external contact with DNA probably via electrostatic binding to the oxygen phosphate backbone of helix causing compression and entire deterioration to the DNA secondary structure . In contrast in the case of L , only concurrent enhancement in the absorption intensity (i. e. hyperchromism) was detected without hypochromism and any significant shift in the wavelength at 274 nm .…”

Section: Dna Binding Studiesmentioning

confidence: 89%

Synthesis and Characterization of Ni(II)/Zn(II) Metal Complexes Derived from Schiff Base and Ortho‐Phenylenediamine: In vitro DNA Binding, Molecular Modeling and RBC Hemolysis

Aazam

Zaki

2020

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Herein, we report the synthesis and characterization of [Ni(L)(o–phenyl)]Cl (1) and [Zn(L)(o–phenyl)]Cl (2) new metal complexes derived from Schiff base ligand of 2–ethoxy–6–((pyrazin–2–ylimino)methyl)phenol (L) and ortho‐phenylenediamine. The biophysical studies of ligand and complexes 1 and 2 have been investigated with CT DNA and experimental outcomes show that both the complexes exhibited higher binding propensity towards DNA as compared to ligand L. Furthermore, molecular docking studies confirmed that both the complexes preferentially bind in the minor groove of DNA. Moreover, 1 trigger the condensation of CT–DNA into compact globules and rod‐shaped morphology revealing electrostatic and intermolecular π–π interactions of ligand moiety present in the DNA–bound complexes. Interestingly, 1 does not produce much hemolysis even at higher concentration of 100 μM. The work is expected to encourage the development of a newer metal complex whose ultimate target is DNA.

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Section: Dna Binding Studiesmentioning

confidence: 89%

Synthesis and Characterization of Ni(II)/Zn(II) Metal Complexes Derived from Schiff Base and Ortho‐Phenylenediamine: In vitro DNA Binding, Molecular Modeling and RBC Hemolysis

Aazam

Zaki

2020

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“…The solid state IR spectrum ( Figure 1) of [Zn(sal)](H 2 O) displayed a characteristic band at 1628 cm −1 due to the Zn(II) coordinated azomethine (C=N) group of the salen scaffold [72]. The bands due to C-H stretching vibrations appeared in the range of 2932-3050 cm −1 [73].…”

Section: Synthesis and Spectroscopic Characterizationmentioning

confidence: 99%

Structural, Spectroscopic, and Chemical Bonding Analysis of Zn(II) Complex [Zn(sal)](H2O): Combined Experimental and Theoretical (NBO, QTAIM, and ELF) Investigation

et al. 2020

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The Zn(II) complex of salen-like scaffold [Zn(sal)](H2O) was synthesized and characterized by elemental analysis, IR, UV–Vis, and 1H-NMR spectroscopic techniques. The structure of complex was confirmed by single crystal X-ray diffraction studies. In the complex, Zn (II) was placed in the inner N2O2 compartment of the salen scaffold in square planar geometry and crystallized in the monoclinic space group P21/n. DFT and TDDFT calculations were performed to reproduce the experimentally observed structural and spectroscopic (IR and UV–vis) findings. The bonding of the Zn(II) framework in the [Zn(sal)](H2O) complex was explored in depth. The theoretical approaches employed were perturbation theory within the context of the natural bond orbital (NBO) framework, and quantum theory of atoms in molecule (QTAIM) and electron localization function (ELF) analysis. The study begins by delineating the difference between the NBO and QTAIM approaches. This paper thus exhibits the supportive nature of NBO theory and QTAIM in discussion of the bonding in the [Zn(sal)](H2O) complex, when both the methodologies are used in combination.

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“…HSA and DNA binding studies were carried out using UV-visible, uorescence quenching and circular dichroism methods and the detailed experimental procedures for these studies have been described elsewhere. 20,[23][24][25][26][27]…”

Section: Binding Of Nanoconjugate With Calf Thymus Dna and Hasmentioning

confidence: 99%

Fluorescent delivery vehicle containing cobalt oxide–umbelliferone nanoconjugate: DNA/protein interaction studies and anticancer activity on MF7 cancer cell line

et al. 2019

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Cu II -Na I heteronuclear complex as anticancer entity against human breast cancer cell lines: DNA binding, cleavage, and Computational studies

Cited by 17 publications

References 47 publications

Synthesis and Characterization of Ni(II)/Zn(II) Metal Complexes Derived from Schiff Base and Ortho‐Phenylenediamine: In vitro DNA Binding, Molecular Modeling and RBC Hemolysis

Synthesis and Characterization of Ni(II)/Zn(II) Metal Complexes Derived from Schiff Base and Ortho‐Phenylenediamine: In vitro DNA Binding, Molecular Modeling and RBC Hemolysis

Structural, Spectroscopic, and Chemical Bonding Analysis of Zn(II) Complex [Zn(sal)](H2O): Combined Experimental and Theoretical (NBO, QTAIM, and ELF) Investigation

Fluorescent delivery vehicle containing cobalt oxide–umbelliferone nanoconjugate: DNA/protein interaction studies and anticancer activity on MF7 cancer cell line

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