Cu(II), Ni(II) and Co(II) complexes with homoscorpionate Bis(2-Mercaptobenzimidazolyl) and Bis(2-Mercaptobenzothiazolyl)borate ligands: Synthesis and in vitro cytotoxicity studies

Faghih, Zeinab; Neshat, Abdollah; Mastrorilli, Piero; Gallo, Vito; Faghih, Zahra; Gilanchi, Shirin

doi:10.1016/j.ica.2020.119896

Cited by 9 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many metal-based complexes have shown anticancer effects through interactions with DNA. ,,,, We used the molecular docking approach to model interactions between the target DNA (PDB ID: 1BNA) and complexes ( 2 , 3 , and 7 ) and predict the binding sites and binding energies. The binding energies were −4.75, −3.55, and −4.53 kcal/mol for 2 , 3 , and 7 , respectively, which were the lowest estimated energies.…”

Section: Resultsmentioning

confidence: 99%

Homobimetallic Au(I)–Au(I) and Heterotrimetallic Au(I)–Fe(II)–Au(I) Complexes with Dialkyldithiophosphates and Phosphine Ligands: Structural Characterization, DFT Analysis, and Tyrosinase Inhibitory and Biological Effects

et al. 2023

Self Cite

View full text Add to dashboard Cite

The role of bridging and terminal ligand electronic and steric properties on the structure and antiproliferative activity of two-coordinated gold(I) complexes was investigated on seven novel binuclear and trinuclear gold(I) complexes synthesized by the reaction of either Au2(dppm)Cl2, Au2(dppe)Cl2, or Au2(dppf)Cl2 with potassium diisopropyldithiophosphate, K[(S-O i Pr)2], potassium dicyclohexyldithiophosphate, K[(S-OCy)2], or sodium bis(methimazolyl)borate, Na(S-Mt)2, which afforded air-stable gold(I) complexes. In 1–7, the gold(I) centers adopt a two-coordinated linear geometry and are structurally similar. However, their structural features and antiproliferative properties highly depend upon subtle ligand substituent changes. All complexes were validated by 1H, 13C{1H}, 31P NMR, and IR spectroscopy. The solid-state structures of 1, 2, 3, 6, and 7 were confirmed using single-crystal X-ray diffraction. A density functional theory geometry optimization calculation was used to extract further structural and electronic information. To investigate the possible cytotoxicities of 2, 3, and 7, in vitro cellular tests were carried out on the human cancerous breast cell line MCF-7. 2 and 7 show promising cytotoxicity.

show abstract

Section: Resultsmentioning

confidence: 99%

Homobimetallic Au(I)–Au(I) and Heterotrimetallic Au(I)–Fe(II)–Au(I) Complexes with Dialkyldithiophosphates and Phosphine Ligands: Structural Characterization, DFT Analysis, and Tyrosinase Inhibitory and Biological Effects

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…A high Cu/Ni ion release rate and high ROS levels in PBS would be more deadly for S. aureus , thus leading to a better antibacterial performance. Furthermore, the antibacterial properties of Cu, Ni, and ROS may also inhibit cell viability [45][46][47][48].These element would also destroy the membrane structure of cell and induced stimulation on adjacent tissue cell [49][50][51].Herein, a fully crystallized surface led to more serious cell toxicity than the polished and partially crystallized surface (Fig. 7).…”

Section: Antibacterial Performancementioning

confidence: 99%

Antibacterial performance of nanosecond laser irradiated zirconium-based bulk metallic glass

Wang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Bulk metallic glass (BMG) have attracted considerable attention during the last decades due to their excellent physical, chemical, and biomedical properties. This report aims to investigate the relationship between antibacterial performance, crystallization behavior and laser ablation parameters of Zr-based bulk metallic glass (Zr-BMG) after nanosecond laser irradiation. The surface morphology, crystallization behavior, surface quality, binding energy and Cu/Ni release properties were explored after laser irradiation. The formation of reactive oxygen species following the immersion of Zr-BMG in phosphate-buffered saline was evaluated using the 2',7'-dichlorofluorescin diacetate method. Staphylococcus aureus was selected to assess the antibacterial performance of Zr-BMG and mouse osteoblasts were used to examine the in vitro cytotoxicity. The results showed that at a laser energy intensity lower than 0.08 J/mm2 the amorphous structure of Zr-BMG was retained after the irradiation process. Furthermore, the laser irradiation process considerably increased the antibacterial performance of Zr-BMG. The Cu/Ni release rate, reactive oxygen species concentration, and antibacterial properties were directly proportional to the laser energy intensity. However, surfaces with a high antibacterial rate also showed high cytotoxicity. The surface irradiated with 7 μJ ablation pulse and 200 mm/s irradiation speed showed a better balance between antibacterial and cytotoxic properties with amorphous status.

show abstract

“…Copper complexes are developed to address challenges that we face in biological and catalysis sciences. [1,2,[10][11][12][13][14][15][16][17][18][19]2,20,[20][21][22][3][4][5][6][7][8][9] In its most stable oxidation states, i. e. I and II, copper ion could facilitate a lot of reactions relevant to the biological and catalysis sciences. Because of its natural abundance and endogenic characteristics, the application of organometallic and coordination compounds of copper has always been surging, in particular in biological sciences.…”

Section: Introductionmentioning

confidence: 99%

“…Copper complexes are developed to address challenges that we face in biological and catalysis sciences [1,2,10–19,2,20,20–22,3–9] . In its most stable oxidation states, i. e. I and II, copper ion could facilitate a lot of reactions relevant to the biological and catalysis sciences.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization, DFT Analysis and Catalysis by Highly Active Cationic Fe(II)‐Cu(I) Complexes in the Green Synthesis of Triazoles in Water

Neshat,

Kakavand,

Cheraghi

et al. 2023

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

Two bimetallic Fe(II)‐Cu(I) complexes, with tetrahedral Cu(I) center stabilized in a S2P2 environment, were synthesized and fully characterized using single crystal X‐ray diffraction, multinuclear NMR, IR and UV‐Visible spectroscopy techniques. Density functional theory with PBE0‐D3(BJ) functional was employed to elucidate the electronic features of these novel metal complexes. The computational analysis revealed that while all Cu(I) complexes adopted a tetrahedral geometry in the gas phase with shorter P−Cu(I) bonds than the S−Cu(I) bonds. These cationic complexes were highly active in the catalytic cycloaddition reaction of azides onto terminal alkynes. The CuAAC reaction were carried out at room temperature with as low as 1 mg (0.1 mol %) of catalyst loading to deliver high yields of the corresponding 1,4 adducts of 1,2,3‐triazoles in water under aerobic conditions.

show abstract

Cu(II), Ni(II) and Co(II) complexes with homoscorpionate Bis(2-Mercaptobenzimidazolyl) and Bis(2-Mercaptobenzothiazolyl)borate ligands: Synthesis and in vitro cytotoxicity studies

Cited by 9 publications

References 45 publications

Homobimetallic Au(I)–Au(I) and Heterotrimetallic Au(I)–Fe(II)–Au(I) Complexes with Dialkyldithiophosphates and Phosphine Ligands: Structural Characterization, DFT Analysis, and Tyrosinase Inhibitory and Biological Effects

Homobimetallic Au(I)–Au(I) and Heterotrimetallic Au(I)–Fe(II)–Au(I) Complexes with Dialkyldithiophosphates and Phosphine Ligands: Structural Characterization, DFT Analysis, and Tyrosinase Inhibitory and Biological Effects

Antibacterial performance of nanosecond laser irradiated zirconium-based bulk metallic glass

Structural Characterization, DFT Analysis and Catalysis by Highly Active Cationic Fe(II)‐Cu(I) Complexes in the Green Synthesis of Triazoles in Water

Contact Info

Product

Resources

About