Cu(ii)-alginate-based superporous hydrogel catalyst for click chemistry azide–alkyne cycloaddition type reactions in water

Abstract

The Cu(ii)-alginate-based superporous hydrogel was prepared and used as a heterogenous catalyst in the regioselective click of 1,4-disubstituted-1,2,3-triazoles by CuAAC reactions.

Alginate Metal Complexes and Their Application

“…Click chemistry is a new approach for drug industries based on the chemical reactions with high yields, and stereo-selectivity results with low reaction time. Bahsis et all [22] studied the synthesis of hydrogel catalyst; consist of sodium alginate with copper (II) for the azide-alkyne cycloaddition in the form of spherical beads. The prepared beads showed high catalytic activity for the required interaction.…”

Alginate modification via click chemistry for biomedical applications

“…During the reaction of CuAAC, Cu(Ⅰ) with catalytic characteristics is difficult to remove from the products. Cu(Ⅱ) could form an excellent polymeric backbone with alginate (Bahsis et al, 2020) . Super porous hydrogels were prepared through coordination of copper (Ⅱ) to a naturally occurring alginate biopolymer via CuAAC.…”

Mechanistic Insights into the Selective Synthesis of 4H-Pyran Derivatives On-Water Using Naturally Occurring Alginate from Sargassum muticum: Experimental and DFT Study

“…Sustainable chemistry has had great interest in the last decade, leading to the investigation and applications of natural polymers such as cellulose, alginate, and hemicellulose in many industrial areas [ 1 , 2 , 3 , 4 ]. Alginates, which are obtained from brown seaweed, play a vital role in the binding and mechanical properties of new materials [ 5 , 6 ]. Its mechanical properties depend on the average molecular weight and the distribution of the three types of molecular fragments (β-D-mannuronic (FM), α-L-guluronic (FG) acids, and heteropolymeric fractions (FMG)) [ 7 , 8 ].…”