Cu(ii)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature

Abstract

A Cu(ii)-catalyzed, effective C–N coupling of 2-aminobenzothiazoles with boronic acids in acetonitrile under open vessel chemistry was achieved.

Recent advances in Chan–Lam coupling reaction

“…Recently, Anilkumar et al established an open-flask Chan–Lam coupling of aryl boronic acids with 2-aminobenzothiazoles. 31 This C–N coupling was accomplished by reacting 2-aminobenzothiazoles with aryl boronic acids in the presence of 10 mol% Cu(OAc) 2 and 20 mol% 1,10-phenanthroline using 1.5 equiv. K 3 PO 4 in CH 3 CN at room temperature for 24 h in an open vessel (Scheme 19).…”