Cu²⁺-doped zeolitic imidazolate frameworks and gold nanoparticle (AuNPs@ZIF-8/Cu) nanocomposites enable label-free and highly sensitive electrochemical detection of oral cancer-related biomarkers

Abstract

It is of great significance to accurately and sensitively detect oral cancer-related biomarker (ORAOV 1) for the early diagnosis of oral cancer. Present here is a novel electrochemical biosensor based...

Application of Sensing Devices in the Detection of Oral, Pulmonary, and Gastrointestinal Diseases

“…The sensor could be used for target molecule detection in spiked saliva samples, exhibiting high recovery rates and potential for large-scale rapid screening for oral cancer diagnosis. Hu et al [37] developed a novel electrochemical biosensor based on Cu 2+ -doped AuNPs@ZIF-8 composite nanomaterials for label-free detection of ORAOV1 in saliva. The sensor demonstrated a wide linear range of 0.1-104 pM and a low detection limit of 63 fM.…”

“…Research on detecting oral cancer through exhaled biomarkers has begun to develop amplified through the RCA reaction [35]. (b) The nanocomposite of AuNPs@ZIF-8/Cu-based construction process of a label-free electrochemical sensor and DNA strand displacement reaction for ORAOV 1 detection [37]. (c) Fabrication of TGF-β1 MIP on primary platinum microelectrodes patterned on glass substrate receptors and detection of TGF-β1 in saliva samples through the fabricated MIP electrochemical sensor [36].…”