Cubosome-based thermosensitive <i>in situ</i> gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy

Mohsen, Amira Mohamed; Salama, Abeer; Asfour, Marwa Hasanein

doi:10.1080/10837450.2023.2216755

Cited by 5 publications

(1 citation statement)

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“…Nanostructured in situ gels of cubosomes are used for the delivery of AD medications. These systems have been utilized in other neurological diseases, such as epilepsy and dementia, for effective treatment [ 173 , 174 ]. Oral nanomedicines using cubosomes have been developed with piperine and tween for the treatment of AD.…”

Section: Advanced Drug Delivery Systems In Epigeneticsmentioning

confidence: 99%

Epigenetic Alterations in Alzheimer’s Disease: Impact on Insulin Signaling and Advanced Drug Delivery Systems

Greeny,

Nair,

Sadanandan

et al. 2024

Biology

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Alzheimer’s disease (AD) is a neurodegenerative condition that predominantly affects the hippocampus and the entorhinal complex, leading to memory lapse and cognitive impairment. This can have a negative impact on an individual’s behavior, speech, and ability to navigate their surroundings. AD is one of the principal causes of dementia. One of the most accepted theories in AD, the amyloid β (Aβ) hypothesis, assumes that the buildup of the peptide Aβ is the root cause of AD. Impaired insulin signaling in the periphery and central nervous system has been considered to have an effect on the pathophysiology of AD. Further, researchers have shifted their focus to epigenetic mechanisms that are responsible for dysregulating major biochemical pathways and intracellular signaling processes responsible for directly or indirectly causing AD. The prime epigenetic mechanisms encompass DNA methylation, histone modifications, and non-coding RNA, and are majorly responsible for impairing insulin signaling both centrally and peripherally, thus leading to AD. In this review, we provide insights into the major epigenetic mechanisms involved in causing AD, such as DNA methylation and histone deacetylation. We decipher how the mechanisms alter peripheral insulin signaling and brain insulin signaling, leading to AD pathophysiology. In addition, this review also discusses the need for newer drug delivery systems for the targeted delivery of epigenetic drugs and explores targeted drug delivery systems such as nanoparticles, vesicular systems, networks, and other nano formulations in AD. Further, this review also sheds light on the future approaches used for epigenetic drug delivery.

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Section: Advanced Drug Delivery Systems In Epigeneticsmentioning

confidence: 99%