Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma

Chen, Zhenzhen; Huang, Qinbiao; Song, Yixuan; Feng, Xianquan; Zeng, Liang; Liu, Zhihong; Hu, Xinran; Tao, Chun; Wang, Lie; Qi, Yan; Song, Hongtao

doi:10.1016/j.biopha.2023.115316

Cited by 19 publications

(5 citation statements)

References 65 publications

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“…When a laser beam hits Au NRs, the light from the laser is absorbed and converted into heat. Due to the local increase in temperature, photoablation occurs, which leads to cell death. , In the case when a cell is exposed to laser action, in which both Se NPs and Au NRs are present, a combination of the two above-mentioned effects occurs, i.e ., oxidative stress and local heating. − It indicates evidence of the synergistic antitumor effects from Se NPs and Au NRs.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Inorganic–Organic Composite Carriers for Synergistic Dual Therapy of Melanoma

Mitusova,

Akhmetova,

Rogova

et al. 2024

ACS Biomater. Sci. Eng.

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Many methods for cancer treatment have been developed. Among them photothermal therapy (PTT) has drawn the most significant attention due to its noninvasiveness, remote control activation, and low side effects. However, a limited depth of light penetration of PTT is the main drawback. To improve the therapeutic efficiency, the development of combined PTT with other therapeutic agents is highly desirable. In this work, we have designed multifunctional composite carriers based on polylactic acid (PLA) particles decorated with gold nanorods (Au NRs) as nanoheaters and selenium nanoparticles (Se NPs) for reactive oxygen species (ROS) production in order to perform a combined PTT against B16−F10 melanoma. To do this, we have optimized the synthesis of PLA particles modified with Se NPs and Au NRs (PLA-Se:Au), studied the cellular interactions of PLA particles with B16−F10 cells, and analyzed in vivo biodistribution and tumor inhibition efficiency. The results of in vitro and in vivo experiments demonstrated the synergistic effect from ROS induced by Se NPs and the heating from Au NRs. In melanoma tumor-bearing mice, intratumoral injection of PLA-Se:Au followed by laser irradiation leads to almost complete elimination of tumor tissues. Thus, the optimal photothermal properties and ROS-generating capacity allow us to recommend PLA-Se:Au as a promising candidate for the development of the combined PTT against melanoma.

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Section: Resultsmentioning

confidence: 99%

Multifunctional Inorganic–Organic Composite Carriers for Synergistic Dual Therapy of Melanoma

Mitusova,

Akhmetova,

Rogova

et al. 2024

ACS Biomater. Sci. Eng.

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“…The most commonly used inorganic compounds are noble metals such as gold (Au) [ 134 ], silver (Ag) [ 135 ], palladium (Pd) [ 136 ], and platinum (Pt) [ 137 ]; carbon-based compounds can also be used, such as graphene [ 138 ], graphene oxide, and carbon dots [ 139 ]. Organic compound-based photothermal therapy uses polymer nanoparticles [ 140 ] and organic dyes [ 141 ], among other materials [ 142 ]. The effectiveness of the photothermal treatment will depend on the ability of the PTAs to convert absorbed light into heat.…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Barba-Rosado,

Carrascal-Hernández,

Insuasty

et al. 2024

Nanomaterials

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Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer is bone cancer, such as osteosarcoma and Ewing tumors, which occur more frequently in infants. This study shows an active interest in the use of graphene oxide and its derivatives in therapy against bone cancer. We present a systematic review analyzing the current state of the art related to the use of GO in treating osteosarcoma, through evaluating the existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications against osteosarcoma were reviewed, which has revealed that there is an excellent trend toward the use of GO-based nanomaterials, based on their thermal and anti-cancer activities, for the treatment of osteosarcoma through various therapeutic approaches. However, more research is needed to develop highly efficient localized therapies. It is suggested, therefore, that photodynamic therapy, photothermal therapy, and the use of nanocarriers should be considered as non-invasive, more specific, and efficient alternatives in the treatment of osteosarcoma. These options present promising approaches to enhance the effectiveness of therapy while also seeking to reduce side effects and minimize the damage to surrounding healthy tissues. The bibliometric analysis of photothermal and photochemical treatments of graphene oxide and reduced graphene oxide from January 2004 to December 2022 extracted 948 documents with its search strategy, mainly related to research papers, review papers, and conference papers, demonstrating a high-impact field supported by the need for more selective and efficient bone cancer therapies. The central countries leading the research are the United States, Iran, Italy, Germany, China, South Korea, and Australia, with strong collaborations worldwide. At the same time, the most-cited papers were published in journals with impact factors of more than 6.0 (2021), with more than 290 citations. Additionally, the journals that published the most on the topic are high impact factor journals, according to the analysis performed, demonstrating the high impact of the research field.

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“…Ex-vivo transdermal permeability of phycocyanin solution and PC-cubosomes was evaluated using modified Franz diffusion cells with a contact area of 3.14 cm 2 and a receptor volume of 8.5 mL (Chen et al, 2023). After removal of hairs and subcutaneous fat, the abdominal skin isolated from SD rats was placed in between the donor and receptor compartments with the stratum corneum (SC) side facing the donor compartment.…”

Section: Ex-vivo Transdermal Permeabilitymentioning

confidence: 99%

Improving the stability and transdermal permeability of phycocyanin loaded cubosomes

Zhu,

Duan,

Jing

et al. 2024

Front. Nanotechnol.

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Instability and low transdermal permeability of protein antioxidants are major obstacles to resist oxidative stress in transdermal drug delivery system. To overcome these shortcomings, cubosomes were developed as an advanced transdermal delivery system to improve stability and transdermal absorption of the model antioxidant phycocyanin in this study. Glyceryl monooleate and poloxamer 407 (P407) were used to prepare cubosomes as carrier matrix and stabilizer, respectively. Phycocyanin loaded cubosomes (PC-cubosomes) were prepared by the emulsification and homogenization method. A 33 full factorial design was used to optimize the cubosome formulations. The final optimal PC-cubosomes possessed an average particle size of 183.2 ± 0.5 nm and a negative surface charge as well as achieved a high encapsulation efficiency of 87.2% ± 2.7%. PC-cubosomes appeared as nano-sized and well-shaped spheres with highly ordered cubical structures. The residual amount of phycocyanin in PC-cubosomes was 3-fold higher than that in the free drug solution after 10 days ultraviolet radiation exposure. In vitro release kinetics of phycocyanin from PC-cubosomes fitted to the Higuchi kinetic model, indicating that phycocyanin released from cubosomes mainly attributed to drug diffusion and dissolution. PC-cubosomes also exhibited higher permeability (39.79 μg⋅cm−2⋅hour−1) across the rat skin than phycocyanin solution (16.33 μg⋅cm−2⋅hour−1). Furthermore, PC-cubosomes were easily taken up by keratinocytes, thereby achieving a prolonged anti-oxidative stress effect. These results therefore suggested that cubosomes could be a promising transdermal delivery system to improve the stability and transdermal permeability of phycocyanin.

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Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma

Cited by 19 publications

References 65 publications

Multifunctional Inorganic–Organic Composite Carriers for Synergistic Dual Therapy of Melanoma

Multifunctional Inorganic–Organic Composite Carriers for Synergistic Dual Therapy of Melanoma

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Improving the stability and transdermal permeability of phycocyanin loaded cubosomes

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