Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine

Wei, Yuanfeng; Zhang, Jianjun; Zheng, Yazhen; Gong, Yongsheng; Meng, Fanrui; Liu, Chengran; Xu, Liang; Sun, Changquan Calvin; Gao, Yuan; Qian, Shuai

doi:10.1039/c8ra10302j

Cited by 34 publications

(32 citation statements)

References 53 publications

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“…Dried CUB and CUBTAM were coated by using Platinum (Pt) using a sputtering technique with a Sputter Coater (Hitachi E-1045, Hitachi, Tokyo, Japan) for 60 s at room temperature. The particle morphology was then observed by a scanning electron microscope (Hitachi SU-70 Schottky, Hitachi, Tokyo, Japan) at 25 mA and 10 kV [21].…”

Section: Polarized Light Microscopy (Plm) and Scanning Electron Micro...mentioning

confidence: 99%

Tamarillo Polyphenols Encapsulated-Cubosome: Formation, Characterization, Stability during Digestion and Application in Yoghurt

2022

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Tamarillo extract is a good source of phenolic and anthocyanin compounds which are well-known for beneficial antioxidant activity, but their bioactivity maybe lost during digestion. In this study, promising prospects of tamarillo polyphenols encapsulated in cubosome nanoparticles prepared via a top-down method were explored. The prepared nanocarriers were examined for their morphology, entrapment efficiency, particle size and stability during in vitro digestion as well as potential fortification of yoghurt. Tamarillo polyphenol-loaded cubosomes showed cubic shape with a mean particle size of 322.4 ± 7.27 nm and the entrapment efficiency for most polyphenols was over 50%. The encapsulated polyphenols showed high stability during the gastric phase of in vitro digestion and were almost completely, but slowly released in the intestinal phase. Addition of encapsulated tamarillo polyphenols to yoghurt (5, 10 and 15 wt% through pre- and post-fermentation) improved the physicochemical and potential nutritional properties (polyphenols concentration, TPC) as well as antioxidant activity. The encapsulation of tamarillo polyphenols protected against pH changes and enzymatic digestion and facilitated a targeted delivery and slow release of the encapsulated compounds to the intestine. Overall, the cubosomal delivery system demonstrated the potential for encapsulation of polyphenols from tamarillo for value-added food product development with yoghurt as the vehicle.

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Section: Polarized Light Microscopy (Plm) and Scanning Electron Micro...mentioning

confidence: 99%

Tamarillo Polyphenols Encapsulated-Cubosome: Formation, Characterization, Stability during Digestion and Application in Yoghurt

2022

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“…One of the well-recognized branched hydrophobic chains with an isoprene unit is phytanyl. Also, some phytanyl chain lipids are more prone to form a nonbilayer structure, which might help the TE of their LipoNPs by disrupting the endosomal membrane during internalization of lipoplexes (Akbar et al, 2017;Astolfi et al, 2019;Hato et al, 1999;Minamikawa & Hato, 1997;Ribeiro et al, 2019;Tran et al, 2016Tran et al, & 2018Wei et al, 2019).…”

Section: Cationic Lipid With Phytanyl Chain Based Liponpsmentioning

confidence: 99%

Liposomal nanoparticles based on steroids and isoprenoids for nonviral gene delivery

Maiti

Bhattacharya

2021

WIREs Nanomed Nanobiotechnol

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Natural lipid molecules are an essential part of life as they constitute the membrane of cells and organelle. In most of these cases, the hydrophobicity of natural lipids is contributed by alkyl chains. Although natural lipids with a nonfatty acid hydrophobic backbone are quite rare, steroids and isoprenoids have been strong candidates as part of a lipid. Over the years, these natural molecules (steroid and isoprenoids) have been used to make either lipid-based nanoparticle or functionalize in such a way that it could form nano assembly alone for therapeutic delivery. Here we mainly focus on the synthetic functionalized version of these natural molecules which forms cationic liposomal nanoparticles (LipoNPs). These cationic LipoNPs were further used to deliver various negatively charged genetic materials in the form of pDNA, siRNA, mRNA (nucleic acids), and so on.

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“…Stirring time was optimized with respect to entrapment e ciency, polydispersity index and particle size of cubosomes. Varying stirring speeds from 1000 to 10000 RPM were optimized so that the formulation doesn't occulate or aggregate [7].…”

Section: Optimization Of Formulation Variables and Process Variablesmentioning

confidence: 99%

Preclinical assessment of nanostructured liquid crystalline particles for the management of bacterial keratitis: in vivo and pharmacokinetics study

Kaul

Nagaich

Verma

2021

Drug Deliv. and Transl. Res.

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The research work was driven to develop novel nanostructured liquid crystalline particles of vancomycin for its improved pre-ocular residence time, ocular bio-availability, enhanced targeting, increased permeability, reduced dosing frequency, controlled drug release and reduced systemic side-effects.Formulation was developed by fragmenting cubic crystalline phase of glycerol monooleate, water and poloxamer 407. A four-factor, three-level Taguchi statistical experimental design was constructed to optimize the formulation. Formulations exhibited internal-cubic structure of the vesicles with particle size in the range of 51.11 ± 0.96 nm to 158.73 ± 0.46 nm and negative zeta potential. Ex-vivo transcorneal permeation studies demonstrated that the optimized cubosomes had 2.4-fold increase in apparent permeability co-e cient as compared to vancomycin solution. Whereas, in-vivo studies in rabbits demonstrated that the severity of keratitis was considerably lowered in day 3 with optimized cubosomes.Ocular pharmacokinetic studies evaluated level of drug in aqueous humor and results revealed that the time to peak concentration (T max ) of vancomycin loaded cubosomal formulation was about 1.9-fold higher and mean residence time was 2.2-fold greater than vancomycin solution. Furthermore, histological examination revealed that the corneal layers displayed well-maintained morphology without any stromal swelling, consequently indicating safety of formulation. In conclusion, results manifested that the developed vancomycin loaded cubosomes could be a promising novel ocular carrier and an ideal substitute for conventional eye-drops for the management of bacterial-keratitis.

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Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine

Abstract: Cubosomes with surface cross-linked chitosan exhibit anti-digestion effect, sustained drug release behavior, and significantly enhanced oral bioavailability of vinpocetine.

Cited by 34 publications

References 53 publications

Tamarillo Polyphenols Encapsulated-Cubosome: Formation, Characterization, Stability during Digestion and Application in Yoghurt

Tamarillo Polyphenols Encapsulated-Cubosome: Formation, Characterization, Stability during Digestion and Application in Yoghurt

Liposomal nanoparticles based on steroids and isoprenoids for nonviral gene delivery

Preclinical assessment of nanostructured liquid crystalline particles for the management of bacterial keratitis: in vivo and pharmacokinetics study

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