2018
DOI: 10.1002/slct.201800263
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CuBr‐Catalyzed Synthesis of Indolizines from Pyridine, Acetophenone and Chalcone under Solvent‐Free Conditions

Abstract: A facile and efficient copper-catalyzed reaction for the synthesis of indolizines from pyridine, acetophenone and chalcone was developed. The reactions were realized under mild and solventfree conditions.

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Cited by 11 publications
(6 citation statements)
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“…These experiments offered proof for the verification of the reaction mechanism. Based on these preliminary experimental results and literature precedents [31,32], we propose a plausible mechanism as shown in Scheme 3. Acetophenone 2a is transformed into 2a' through enolization, and then it reacts with one molecule of CuBr2 to produce an intermediate A, with HBr as a byproduct.…”
Section: Entry 17)mentioning
confidence: 63%
“…These experiments offered proof for the verification of the reaction mechanism. Based on these preliminary experimental results and literature precedents [31,32], we propose a plausible mechanism as shown in Scheme 3. Acetophenone 2a is transformed into 2a' through enolization, and then it reacts with one molecule of CuBr2 to produce an intermediate A, with HBr as a byproduct.…”
Section: Entry 17)mentioning
confidence: 63%
“…In 2018, we reported a new and practical strategy for the synthesis of indolizines from acetophenones, pyridines, and chalcones in the presence of CuBr under solvent-free conditions (Scheme 7). 11…”
Section: Methodsmentioning
confidence: 99%
“…have been synthesized from aromatic or aliphatic olefins and α-picoline derivatives; 9 2,3-disubstituted NH-indoles have been prepared from arylnitrones and diazo compounds; 10 and indolizines have been prepared from pyridines, acetophenones, and chalcones by our groups in 2018. 11 Oxidative cyclization is a reaction of great importance to organic synthesis. The conversion of acyclic precursors into cyclized products can provide transformed scaffolds, specialized structures, or bioactivity.…”
Section: Dong Wang Was Born Inmentioning
confidence: 99%
“…A solvent‐free CuBr‐catalysed multicomponent synthesis of indolizines from pyridine, acetophenone and chalcones was reported . The best conditions were found to be by using CuBr (0.3 equiv.)…”
Section: Synthesis Of Heterocyclesmentioning
confidence: 99%