Cucurbit[7]uril-Capped Hybrid Conjugated Oligomer-Gold Nanoparticles for Combined Photodynamic-Photothermal Therapy and Cellular Imaging

Özkan, Melis; Hadi, Seyed Ehsan; Tunç, İlknur; Midilli, Yakup; Ortaç, Bülend; Tuncel, Dönüş

doi:10.1021/acsapm.0c00540

Cited by 13 publications

(18 citation statements)

References 48 publications

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“…The positive zeta potential values (21 ± 1 mV) of the UC@CB [7] nanohybrids dispersed in milliQ-water are in accordance with the presence of CB [7] as a capping as reported for other CB [7]-capped nanoparticles [41,42].…”

Section: Discussionsupporting

confidence: 87%

Initial Biological Assessment of Upconversion Nanohybrids

et al. 2021

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Nanoparticles for medical use should be non-cytotoxic and free of bacterial contamination. Upconversion nanoparticles (UCNPs) coated with cucurbit[7]uril (CB[7]) made by combining UCNPs free of oleic acid, here termed bare UCNPs (UCn), and CB[7], i.e., UC@CB[7] nanohybrids, could be used as photoactive inorganic-organic hybrid scaffolds for biological applications. UCNPs, in general, are not considered to be highly toxic materials, but the release of fluorides and lanthanides upon their dissolution may cause cytotoxicity. To identify potential adverse effects of the nanoparticles, dehydrogenase activity of endothelial cells, exposed to various concentrations of the UCNPs, was determined. Data were verified by measuring lactate dehydrogenase release as the indicator of loss of plasma membrane integrity, which indicates necrotic cell death. This assay, in combination with calcein AM/Ethidium homodimer-1 staining, identified induction of apoptosis as main mode of cell death for both particles. The data showed that the UCNPs are not cytotoxic to endothelial cells, and the samples did not contain endotoxin contamination. Higher cytotoxicity, however, was seen in HeLa and RAW 264.7 cells. This may be explained by differences in lysosome content and particle uptake rate. Internalization of UCn and UC@CB[7] nanohybrids by cells was demonstrated by NIR laser scanning microscopy.

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Section: Discussionsupporting

confidence: 87%

Initial Biological Assessment of Upconversion Nanohybrids

et al. 2021

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“…Because of the unique property of the rigid confined spaces including the polar portals rimmed with carbonyl groups, Q[ n ] hosts have attracted continuous attention for the construction of various Q[ n ] triggered assemblies of nanoparticles via host–guest interactions, − but there are few examples of supramolecular luminescent emission systems derived from the assembly of Q[ n ] particles. In 2020, Ma and co-workers used Q[7] and Q[8] to prepare bright Au nanoclusters in water via host–guest-interaction triggered supramolecular assemblies (Figure a) .…”

Section: Supramolecular Organic Luminescent Emissions From Q[n] Parti...mentioning

confidence: 99%

Assembly and Applications of Macrocyclic-Confinement-Derived Supramolecular Organic Luminescent Emissions from Cucurbiturils

et al. 2022

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Cucurbit[n]urils (Q[n]s or CB[n]s), as a classical of artificial organic macrocyclic hosts, were found to have excellent advantages in the fabricating of tunable and smart organic luminescent materials in aqueous media and the solid state with high emitting efficiency under the rigid pumpkin-shaped structure-derived macrocyclic-confinement effect in recent years. This review aims to give a systematically up-to-date overview of the Q[n]based supramolecular organic luminescent emissions from the confined spaces triggered host−guest complexes, including the assembly fashions and the mechanisms of the macrocycle-based luminescent complexes, as well as their applications. Finally, challenges and outlook are provided. Since this class of Q[n]-based supramolecular organic luminescent emissions, which have essentially derived from the cavity-dependent confinement effect and the resulting assembly fashions, emerged only a few years ago, we hope this review will provide valuable information for the further development of macrocycle-based light-emitting materials and other related research fields.

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“…This reflected the potential of CB [7] in reducing the toxicity upon its capping onto such nanoparticles under dark conditions. 31 However, under white light irradiation (20 mW/cm 2 , 20 min), CB [7]-nanocomplex and oligomer-Aunanoparticles had shown higher cytotoxicity (MCF7 cell viability decreased to ∼28%, 10%, and 0.5% with the corresponding concentrations of 13.1, 39.4, and 118 μg/mL) compared to lower cytotoxicity revealed with bare oligomer and oligomer@CB [7] (∼55%, 40%, and 28% reduction with the same corresponding concentrations of 13.1, 39.4, and 118 μg/ mL). 31 The favorable photoresponsivity and photocytotoxicity of similar CB [7]-based nanocomplexes make them suitable for cancer photodynamic therapy.…”

Section: Cb-based Stimuli-responsive Nanovesicles Inmentioning

confidence: 99%

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

Alabrahim

Fahmy²,

Azzazy

2023

ACS Appl. Nano Mater.

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Chemotherapeutics commonly exhibit low bioavailability and systemic adverse effects. Supramolecular nanovesicles, such as pillar[n]arenes, calix[n]arenes, cucurbit[n]urils (CBs), and cyclodextrins, have been introduced as promising nanocarriers due to their remarkable encapsulation capacity and ability to host hydro-philic/-phobic guest molecules. Additionally, such nanovesicles can be decorated with various stimuli-responsive entities to enable drug targeting and controlled drug release. Self-assembly of amphiphilic cavitands and host−guest complexation represent the two common approaches for preparation of supramolecular nanovesicles with customizable surfaces capable of accommodating different biologically active guest molecules. CBs have been used as smart and multifunctional host macromolecules in cancer therapy. CBs are fabricated via a condensation reaction between formaldehyde and glycoluril units generating barrel-shaped supramolecules with partially enclosed cavities. The unique structure of CBs surrounding an internal hydrophobic cavity allows them to accommodate cationic and neutral guest molecules via ion-dipole and hydrophobic interactions, respectively. Additionally, CBs are stable, safe, and biocompatible, and their surfaces can be decorated with various functional targeting moieties. These advantages have promoted CBs as promising candidates for stimuli-responsive targeted delivery of chemotherapeutics. This review presents the most recent advances in the design of stimuli-responsive nanosystems based on CBs for effective cancer treatment.

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Cucurbit[7]uril-Capped Hybrid Conjugated Oligomer-Gold Nanoparticles for Combined Photodynamic-Photothermal Therapy and Cellular Imaging

Cited by 13 publications

References 48 publications

Initial Biological Assessment of Upconversion Nanohybrids

Initial Biological Assessment of Upconversion Nanohybrids

Assembly and Applications of Macrocyclic-Confinement-Derived Supramolecular Organic Luminescent Emissions from Cucurbiturils

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

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