Cucurbitacin E’s Anti-Cancer Effects on HCT116 Human Colon Cancer Cells by Controlling Expression and Phosphorylation levels of Caspase-9, eIF-2α, and ATF-4
Abstract:Cucurbitacin E is a pivotal member of the cucurbitacin family and has been shown to have anti-cancer effects. However, until now, the anti-cancer effect and mode of action of cucurbitacin E in human colon cancer cells remain unclear. In this study, we investigated whether cucurbitacin E inhibits the growth of HCT116 human colorectal cancer cells. Treatment of cucurbitacin E at 1 µM markedly reduced the survival of HCT116 cells. Moreover, treatment of cucurbitacin E at 1 µM caused nuclear DNA fragmentation in H… Show more
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