Cucurbitacin IIb, a steroidal triterpene from Ibervillea sonorae induces antiproliferative and apoptotic effects on cervical and lung cancer cells

Torres-Moreno, Heriberto; Marcotullio, Maria Carla; Velázquez, Carlos; Ianni, Federica; Garibay‐Escobar, Adriana; Robles‐Zepeda, Ramón Enrique

doi:10.1016/j.steroids.2020.108597

Cited by 31 publications

(21 citation statements)

References 20 publications

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“…Other studies found that wereke has anticancer potential, in that it possesses a cytotoxic effect on T47D cancer cell lines [ 110 ] due the presence of cucurbitan-type triterpene glycosides. The isolation of Cucurbitacin IIb and the effect of the reduction in the growth of cancer cells, as well as the induction of apoptosis in HeLA and A549 at low doses, were reported by Robles-Zepeda et al [ 111 ]. The structural differences of Cucurbitacin IIb with the less active Kinoin A and Kinoin B diglycoside, were the subject of study, where the presence in the molecule at position 2 of a hydroxyl group with β orientation, was found to enhance antiproliferative activity [ 112 ].…”

Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 86%

“…In this manner, even with the presence of cucurbitacins, the antidiabetic properties observed in wereke were not clearly associated with these. Moreover, the cucurbitacins of wereke showed potent anticancer activity, and at present, a number of related investigations are in progress [ 111 , 112 , 113 ]. In a similar situation, the cucurbitacins present in S. edule are predominantly cucurbitancins B, E, P, and L, but pharmacological studies have described the flavonoids as the most relevant phytochemicals for hypoglycemic effects [ 134 ].…”

Section: Discussionmentioning

confidence: 99%

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Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

et al. 2022

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In Mexico, Diabetes mellitus (DM) is a serious health problem, and although the current pharmacological treatments for DM such as insulin and oral hypoglycemics are available, the Mexican population continues to use medicinal plants in the treatment of DM. The antidiabetic properties of the plant species that belong to the Cucurbitaceae family has already been recognized worldwide. Since Mexico is one of the most important centers of diversity of Cucurbitaceae, the present work contributes to the review of the most used species of Cucurbitaceae in the treatment of DM in Mexico. The reviewed species (Cucurbita ficifolia, C. maxima, C. moschata, C. pepo, Ibervillea sonorae, Sechium edule, Citrullus lanatus, Cucumis melo, and C. sativus) revealed that the antidiabetic effects exerted are effective in a number of mechanisms involved in the complex pathogenesis of DM: hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, protective effects on diverse organs and cells, as well as in the control of dyslipidemias; furthermore, the select species of the Cucurbitaceae family could also be essential components of diets for the control of DM in patients with the disease. Thus, the Cucurbitaceae species selected in the present work represent a source of antidiabetic agents that perhaps establish the bases for novel clinical treatments.

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Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

et al. 2022

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“…CuIIb, a member of cucurbitacins, was isolated from the root of Hemsleya amabilis , and used to the treatment of acute tonsillitis, enteritis and bacillary dysentery as a folk remedy 27 . Recently, Torres‐Moreno et al 28 demonstrated that CuIIb could impede the progression of cervical and lung cancer through anti‐proliferative and pro‐apoptosis. Here, two doses of CuIIb were used to treat SLE mice.…”

Section: Discussionmentioning

confidence: 99%

Cucurbitacin IIb improved active chromatin‐induced systemic lupus erythematosus via balancing the percentage of Th17 and Treg cells

Dong

et al. 2020

Clin Exp Pharma Physio

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The pathogenesis of systemic lupus erythematosus (SLE) is closely associated with aberrant immune system. Here, the aim of our study was to explore the regulation of cucurbitacin IIb (CuIIb) to Th17/Treg cells in SLE. Compared with normal mice, the percentage of Treg cells was downregulated in SLE mouse model, and Th17 was upregulated. Meantime, the production of Treg‐related transcription factor (foxp3) in SLE model mouse was reduced, and the production of Th17‐related transcription factor (RORγt) was increased. After treatment with CuIIb, the percentage of Treg cells in SLE mice was partly upregulated, and Th17 cells percentage was downregulated. The expression of foxp3 and RORγt in SLE mice were promoted and inhibited by CuIIb treatment, respectively. SLE‐induced kidney injury also was improved by CuIIb treatment. In vitro, we demonstrated again that CuIIb upregulated the percentage of Treg cells in lymphocytes from SLE mice, and downregulated the percentage of Th17 cells. Highly expressed IL‐6 and IL17, and lowly expressed IL‐10 and TGF‐β in lymphocytes from SLE mice were repressed and facilitated by CuIIb treatment, respectively. Overall, our data proved that CuIIb improved kidney injury in SLE mice through balancing the percentage of Th17 and Treg cells. Our data provided a reliable evidence to support the potential of CuIIb in SLE treatment.

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“…A representative of the tetracyclic triterpene group, cucurbitacin E (Cucumic melo L.), was assessed in vitro on two cervical cancer cell lines HeLa and CaSki and revealed increased apoptotic processes and irreversible cell cycle arrest in the G2/M phase as well as the up-regulation of the death receptor DR5 in a dose-dependent manner; no necrotic events were reported (168). Another tetracyclic triterpene, cucurbitacin IIb (23,24dihydrocucurbitacin F) isolated from the methanolic extract of Ibervillea sonorae (S. Watson) Greene pronouncedly inhibited the proliferation of HeLa cells and induced apoptotic cell death in a selective manner (169).…”

Section: Cervical Cancermentioning

confidence: 99%

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

et al. 2021

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Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Sex hormone-dependent cancers share a common and rather unique carcinogenesis mechanism involving the active role of endogenous and exogenous sex hormones to maintain high mitotic rates and increased cell proliferation thus increasing the probability of aberrant gene occurrence and accumulation highly correlated with abnormal cell division and the occurrence of malignant phenotypes. Cancer related hormone therapy has evolved, currently being associated with the blockade of other signaling pathways often associated with carcinogenesis and tumor progression in cancers, with promising results. However, despite the established developments, there are still several shortcomings to be addressed. Triterpenes are natural occurring secondary metabolites biosynthesized by various pathways starting from squalene cyclization. Due to their versatile therapeutic potential, including the extensively researched antiproliferative effect, these compounds are most definitely a cornerstone in the research and development of new natural/semisynthetic anticancer therapies. The present work thoroughly describes the ongoing research related to the antitumor activity of triterpenes in sex hormone-dependent cancers. Also, the current review highlights both the biological activity of various triterpenoid compounds and their featured mechanisms of action correlated with important chemical structural features.

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Cucurbitacin IIb, a steroidal triterpene from Ibervillea sonorae induces antiproliferative and apoptotic effects on cervical and lung cancer cells

Cited by 31 publications

References 20 publications

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

Cucurbitacin IIb improved active chromatin‐induced systemic lupus erythematosus via balancing the percentage of Th17 and Treg cells

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

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