Cucurbitacin <scp>II</scp>a: A review of phytochemistry and pharmacology

Zeng, Yijia; Wang, Jin; Huang, Qinwan; Ren, Yuanyuan; Li, Tingna; Zhang, Xiaorui; Yao, Renchuan; Sun, Jilin

doi:10.1002/ptr.7077

Cited by 16 publications

(5 citation statements)

References 125 publications

(143 reference statements)

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“…The induction of apoptosis and autophagy, and cell cycle arrest have been reported to be involved in the anticancer mechanism of CUIIa ( 20 , 23 , 24 ). Consistently, CUIIa significantly inhibited the viability and colony formation of liver cancer cells in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Cucurbitacin IIa (CUIIa) is a biologically active tetracyclic triterpenoid found in Cucurbitaceae . CUIIa has attracted considerable attention because of its anti-inflammatory and antiviral properties ( 20 , 21 ). Although the anticancer mechanisms of several cucurbitacins have been elucidated, the anticancer activity is rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

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Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer

Li,

Wang,

Zhang

et al. 2024

Int J Oncol

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The immunogenic cell death (ICD) has aroused great interest in cancer immunotherapy. Doxorubicin (DOX), which can induce ICD, is a widely used chemotherapeutic drug in liver cancer. However, DOX-induced ICD is not potent enough to initiate a satisfactory immune response. Cucurbitacin IIa (CUIIa), a tetracyclic triterpene, is a biologically active compound present in the Cucurbitaceae family. The present study assessed the effects of the combination of DOX and CUIIa on the viability, colony formation, apoptosis and cell cycle of HepG2 cells. In vivo anticancer effect was performed in mice bearing H22 tumor xenografts. The hallmark expression of ICD was tested using immunofluorescence and an ATP assay kit. The immune microenvironment was analyzed using flow cytometry. The combination of CUIIa and DOX displayed potent apoptosis inducing, cell cycle arresting and in vivo anticancer effects, along with attenuated cardiotoxicity in H22 mice. The combination of DOX and CUIIa also facilitated ICD as manifested by elevated high-mobility group box 1, calreticulin and ATP secretion. This combination provoked a stronger immune response in H22 mice, including dendritic cell activation, increment of cytotoxic T cells and T helper 1 cells. Moreover, the proportion of immunosuppressive cells including myeloid-derived suppressor cells, T regulatory cells and M2-polarized macrophages, decreased. These data suggested that CUIIa is a promising combination partner with DOX for liver cancer treatment, probably via triggering ICD and remolding the immune microenvironment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer

Li,

Wang,

Zhang

et al. 2024

Int J Oncol

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“…It is essential to highlight that Angelica sinensis is commonly utilized in this formula to enhance blood quality and facilitate blood circulation[ 78 ]. Zeng et al [ 79 ] reviewed 26 randomized controlled trials on XYS for depression. The results showed that XYS and antidepressants were equally effective.…”

Section: Overview Of Tcmmentioning

confidence: 99%

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Yang,

Chen,

Xie

2024

World J Psychiatry

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Depression, a prevalent and complex mental health condition, presents a significant global health burden. Depression is one of the most frequent mental disorders; deaths from it account for 14.3% of people worldwide. In recent years, the integration of complementary and alternative medicine, including traditional Chinese medicine (TCM), has gained attention as a potential avenue for addressing depression. This comprehensive review critically assesses the efficacy of TCM interventions in alleviating depressive symptoms. An in-depth look at different research studies, clinical trials, and meta-analyses is used in this review to look into how TCM practices like herbal formulations, acupuncture, and mind-body practices work. The review looks at the quality of the evidence, the rigor of the methods, and any possible flaws in the current studies. This gives us an idea of where TCM stands right now in terms of treating depression. This comprehensive review aims to assess the efficacy of TCM interventions in alleviating depressive symptoms. In order to learn more about their possible healing effects, the study also looks into how different types of TCM work, such as herbal formulas, acupuncture, and mind-body practices.

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“…Thus, the structure of 6 was elucidated as depicted, named siragrosvenin F. In addition, eight known compounds were isolated from the roots of S. grosvenorii. Their structures were identified as 23,24dihydrocucurbitacin F (7) (Guerrero-Analco et al, 2007), cucurbitacin IIa (8) (Zeng et al, 2021), cucurbitacin Q1 (9) (Add El-Fattah, 1994), jinfushanencin F (10) (Li et al, 2016), siraitic acid A (11) (Si et al, 1999), siraitic acid B (12) (Si et al, 1999), cucurbitacin E (13) (Attard et al, 2005), and 23,24dihydrocucurbitacin E ( 14) (Tang et al, 2015).…”

Section: Compound Structure Elucidationmentioning

confidence: 99%

Novel Triterpenoid Alkaloids With Their Potential Cytotoxic Activity From the Roots of Siraitia grosvenorii

Wang

et al. 2022

Front. Chem.

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Four novel triterpenoid alkaloids, siragrosvenins A–D (1–4), and two new cucurbitane-type triterpenoids, siragrosvenins E–F (5, 6), together with eight known analogs (7−14), were isolated from the roots of Siraitia grosvenorii. Compounds 1−4 possessed a rare cucurbitane-type triterpenoid scaffold, featuring an extra pyrazine unit via the Strecker reaction in the cucurbitane framework. Compound 5 displayed a 6/6/6/5/6/5-fused polycyclic ring system, with an uncommon fused furan and pyran ring in the side chain. All the structures were characterized by extensive spectroscopic analysis, including HRESIMS, NMR, and X-ray crystallographic data. It is worth noting that the DP4+ analysis method was applied for the first time to determine the absolute configurations of the trihydroxybutyl moiety in the side chain of compounds 1–4. In vitro cytotoxicity screening found that compounds 4, 8, 9, 13, and 14 exhibited remarkable cytotoxic activities against three cell lines with IC50 values ranging from 1.44 to 9.99 μM. Siragrosvenin D shows remarkable cytotoxic activity on MCF-7 cells. As a result, it inhibited the proliferation of MCF-7 cells and reduced their viability via the induction of G2/M phase arrest and significantly induced apoptosis in MCF-7 cells.

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Cucurbitacin IIa: A review of phytochemistry and pharmacology

Cited by 16 publications

References 125 publications

Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer

Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Novel Triterpenoid Alkaloids With Their Potential Cytotoxic Activity From the Roots of Siraitia grosvenorii

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