2014
DOI: 10.1080/19768354.2014.886619
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Cudratricusxanthone A inhibits endothelial protein C receptor shedding in vitro and in vivo

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(1 citation statement)
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“…22 Moreover, CTXA could exert anti-soluble endothelial cell protein C receptor (anti-sEPCR) shedding activity against vascular inammation via inhibiting the expression of TNF-a-converting enzyme induced by phorbol-12-myristate-13-acetate in endothelial cells. 89 Cudraavone B was not only a potent inhibitor of TNF-a by blocking the translocation of NF-kB from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocytic leukemia cell line, but was also an inhibitor of COX-1 and COX-2 with higher selectivity toward COX-2, which suggested that it could be used as a lead for the development of nonsteroidal anti-inammatory drugs. 60…”
Section: Anti-inammatory Activitymentioning
confidence: 99%
“…22 Moreover, CTXA could exert anti-soluble endothelial cell protein C receptor (anti-sEPCR) shedding activity against vascular inammation via inhibiting the expression of TNF-a-converting enzyme induced by phorbol-12-myristate-13-acetate in endothelial cells. 89 Cudraavone B was not only a potent inhibitor of TNF-a by blocking the translocation of NF-kB from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocytic leukemia cell line, but was also an inhibitor of COX-1 and COX-2 with higher selectivity toward COX-2, which suggested that it could be used as a lead for the development of nonsteroidal anti-inammatory drugs. 60…”
Section: Anti-inammatory Activitymentioning
confidence: 99%