Cudraxanthone L inhibits gastric cancer by regulating the MAPK signalling and promoting FAS-mediated pathway

Zhang, Jiamei; Sun, Hongtao; Jiang, Kunxiu; Song, Xingzhuo; Wang, Xirui; Yang, Yuqian; Liu, Hanying; Ji, Qingxuan; Yu, Xue; Liu, Yonggang; Han, Jing; Wang, Wei

doi:10.1016/j.biopha.2021.111876

Cited by 10 publications

(5 citation statements)

References 35 publications

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“…Changes to signaling pathways in tumor cells are closely associated with cell proliferation and apoptosis. 39 The MAPK signaling pathway plays an important physiological role in eukaryotes, 40,41 which also primarily includes the p38, JNK, and ERK pathways that can be activated or inhibited to participate in cell proliferation, differentiation, and apoptosis. 42,43 In general, after activation of RAF in the MAPK pathway, RAF binds to MEK to form the cRAF-MEK1 complex through the C-terminus.…”

Section: Discussionmentioning

confidence: 99%

Discovery of the mechanism of n-propylparaben-promoting the proliferation of human breast adenocarcinoma cells by activating human estrogen receptors via metabolomics analysis

et al. 2023

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Background N-propylparaben (PP), a type of paraben, is commonly used as a preservative or antibacterial agent in daily chemicals, medicine, food, cosmetics, feed, and various industrial preservatives. Although PP promotes the growth of human breast adenocarcinoma (MCF-7) cells by activating the human estrogen receptor (ER), the mechanism responsible for this type of programmed cell proliferation is poorly understood. Objective To clarify the effect of PP on cell metabolic function and the potential molecular mechanism of PP induced MCF-7 cell proliferation from a new perspective. Methods To use high-resolution mass spectrometry-based metabolomics combined with bioinformatics analysis to analyze the molecular mechanism. Results The results illustrated that differential endogenous compounds related to the effects of PP on cell metabolic functions were detected. PP was found to promote glycolysis in MCF-7 cells and enhance the tricarboxylic acid cycle (TCA cycle) in mitochondria, thus improving the energy supply to these tumor cells for metabolic function and promotion of rapid proliferation. Moreover, we found that PP promoted cell proliferation by affecting the mitogen-activated protein kinase (MAPK) signaling pathway of MCF-7 cells. Conclusion Our results revealed the molecular mechanism of low concentration PP promoting MCF-7 cell proliferation by activating ER.

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Section: Discussionmentioning

confidence: 99%

Discovery of the mechanism of n-propylparaben-promoting the proliferation of human breast adenocarcinoma cells by activating human estrogen receptors via metabolomics analysis

et al. 2023

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“…CalliSpheres Beads loaded EPI in a common manner ( 3 , 16 ). CPT was dissolved in a solvent comprising dimethyl sulfoxide, hydroxymethyl cellulose, and Tween-80 ( 17 ). NRF2, HO-1 and NQO1 antibodies were obtained from Servicebio (Wuhan, China).…”

Section: Methodsmentioning

confidence: 99%

Experimental study of camptothecin combined with drug-eluting bead transarterial chemoembolization in the rabbit VX2 liver tumor model

Meng

Liu

et al. 2022

Front. Oncol.

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Drug-eluting bead transarterial chemoembolization (DEB-TACE) has been widely used in the treatment of liver cancer; however, the utilization rate of chemotherapeutic drugs after embolization is low. Chemotherapy resistance mediated by high nuclear factor E2-related factor 2 (NRF2) expression limits DEB-TACE efficacy. Camptothecin (CPT), an NRF2 inhibitor, exerts chemosensitizing effects. We designed a controlled experiment to determine the efficacy and feasibility of DEB-TACE combined with CPT for the treatment of rabbit VX2 hepatoma. DEB-TACE activated NRF2 expression in the tumor region. NRF2 activation could be inhibited by the combined use of CPT. After DEB-TACE alone, the tumor necrosis was incomplete, there were still highly active tumor residues, and the apparent diffusion coefficient (ADC) value, which was negatively correlated with tumor activity observed by magnetic resonance imaging, remained low. After DEB-TACE combined with CPT, the relative necrosis of the tumor was more complete, the ADC value was higher, and the ADC change was greater. The single application of CPT did not result in evident liver function and physical burden to the rabbits. The combined use of CPT and DEB-TACE did not significantly increase DEB-TACE imaging of liver function and body. In conclusion, CPT can also inhibit high NRF2 expression after DEB-TACE treatment. Combining CPT with DEB-TACE can improve the sensitivity of DEB-TACE in the treatment of VX2 tumors, improve the therapeutic effect, and has no evident toxic and side effects. This study explored the methods for enhancing the efficacy of DEB-TACE in liver cancer from a new perspective and performed model experiments, which provided a theoretical basis for future clinical treatment.

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“…The mitogen-activated protein kinase (MAPK) signaling pathway plays an important physiological role in eukaryotic cells [ 210 ], mainly including p38, JNK, and ERK pathways, which participate in many bioprocesses, such as cell proliferation, differentiation, apoptosis, and so on [ 211 ]. Among them, the p38 pathway can promote cell apoptosis by activating c-Jun and increasing TNF-α expression.…”

Section: Potential Mechanisms Of Plant-derived Natural Products In Th...mentioning

confidence: 99%

Research Progress of Plant-Derived Natural Products against Drug-Resistant Cancer

Liu,

Wang,

Xia

et al. 2024

Nutrients

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As one of the malignant diseases globally, cancer seriously endangers human physical and mental health because of its high morbidity and mortality. Conventional cancer treatment strategies, such as surgical resection and chemoradiotherapy, are effective at the early stage of cancer but have limited efficacy for advanced cancer. Along with cancer progress and treatment, resistance develops gradually within the population of tumor cells. As a consequence, drug resistance become the major cause that leads to disease progression and poor clinical prognosis in some patients. The mechanisms of cancer drug resistance are quite complex and involve various molecular and cellular mechanisms. Therefore, exploring the mechanisms and finding specific targets are becoming imperative to overcome drug resistance. In recent years, plant-derived natural products have been evaluated as potential therapeutic candidates against cancer with drug resistance due to low side effects and high anticancer efficacy. A growing number of studies have shown that natural products can achieve superior antitumor effects through multiple signaling pathways. The mechanisms include regulation of multiple drug resistance (MDR)-related genes, inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, induction of autophagy, and blockade of the cell cycle. This paper reviews the molecular and cellular mechanisms of cancer drug resistance, as well as the therapeutic effects and mechanisms of plant-derived natural products against cancer drug resistance. It provides references for developing therapeutic medication for drug-resistant cancer treatment with high efficacy and low side effects.

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Cudraxanthone L inhibits gastric cancer by regulating the MAPK signalling and promoting FAS-mediated pathway

Cited by 10 publications

References 35 publications

Discovery of the mechanism of n-propylparaben-promoting the proliferation of human breast adenocarcinoma cells by activating human estrogen receptors via metabolomics analysis

Discovery of the mechanism of n-propylparaben-promoting the proliferation of human breast adenocarcinoma cells by activating human estrogen receptors via metabolomics analysis

Experimental study of camptothecin combined with drug-eluting bead transarterial chemoembolization in the rabbit VX2 liver tumor model

Research Progress of Plant-Derived Natural Products against Drug-Resistant Cancer

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