Cue-evoked dopamine release in the nucleus accumbens shell tracks reinforcer magnitude during intracranial self-stimulation

Beyene, Manna; Carelli, Regina M.; Wightman, R. Mark

doi:10.1016/j.neuroscience.2010.06.047

Cited by 41 publications

(42 citation statements)

References 39 publications

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“…Specifically, DA D 2 receptor blockade in the core and shell have opposing effects on impulsivity, with increasing impulsivity consequent to core blockade and decreasing impulsivity with shell blockade (Besson et al 2010). Likewise, DA release in the nAc shell scales with reward magnitude (Beyene et al 2010), and inactivating the nAc shell decreases preference for larger vs. smaller rewards (Stopper and Floresco 2011). Furthermore, a reward-predicting cue elicits increases in phasic DA release in both the nAc core and shell, but such DA increases are greater and more sustained in the shell (Cacciapaglia et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults

Smith

Wallace

Dang

et al. 2016

Journal of Neurophysiology

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Section: Discussionmentioning

confidence: 99%

Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults

Smith

Wallace

Dang

et al. 2016

Journal of Neurophysiology

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“…The ability of VTA AmyR signaling to modulate DA signaling to these other sites remains untested, but represents an extremely important extension of the current results. For example, DA signaling in the NAc shell is relevant for many aspects of feeding and food reward (Baldo and Kelley, 2007;Bassareo and Di Chiara, 1999;Beyene et al, 2010). The dopaminergic projection from the VTA to the shell may also contribute to the intake-suppressive effects of VTA AmyR activation.…”

Section: Discussionmentioning

confidence: 99%

Amylin Modulates the Mesolimbic Dopamine System to Control Energy Balance

Mietlicki‐Baase

Reiner

Cone

et al. 2014

Neuropsychopharmacol

103

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Amylin acts in the CNS to reduce feeding and body weight. Recently, the ventral tegmental area (VTA), a mesolimbic nucleus important for food intake and reward, was identified as a site-of-action mediating the anorectic effects of amylin. However, the long-term physiological relevance and mechanisms mediating the intake-suppressive effects of VTA amylin receptor (AmyR) activation are unknown. Data show that the core component of the AmyR, the calcitonin receptor (CTR), is expressed on VTA dopamine (DA) neurons and that activation of VTA AmyRs reduces phasic DA in the nucleus accumbens core (NAcC). Suppression in NAcC DA mediates VTA amylin-induced hypophagia, as combined NAcC D1/D2 receptor agonists block the intake-suppressive effects of VTA AmyR activation. Knockdown of VTA CTR via adeno-associated virus short hairpin RNA resulted in hyperphagia and exacerbated body weight gain in rats maintained on high-fat diet. Collectively, these findings show that VTA AmyR signaling controls energy balance by modulating mesolimbic DA signaling.

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“…Although previous work suggests that shell may be more biased toward reward encoding in learning tasks (Beyene et al, 2010;Cacciapaglia et al, 2012;Saddoris et al, 2015a;Saddoris et al, 2013;Stopper and Floresco, 2011), no studies have compared core and shell DA signaling for unsignaled rewards. Here we measured rapid DA release in the core and shell of drug-naive and cocaine-experienced rats while they received unsignaled presentations of rewards of different magnitudes (1 pellet or 2 pellets) and later tested their sensitivity to reward magnitude in a Free Choice task.…”

Section: Introductionmentioning

confidence: 99%

Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell

Saddoris

Sugam

Carelli

2016

Neuropsychopharmacol

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Dopamine signals have repeatedly been linked to associative learning and motivational processes. However, there is considerably less agreement on a role for dopamine in reward processing, and therefore whether neuroplastic changes in dopamine function following chronic exposure to drugs of abuse such as cocaine may impair appropriate valuation of rewarding stimuli. To quantify this, we voltammetrically measured real-time dopamine release in the nucleus accumbens (NAc) core or shell while rats received unsignaled deliveries of either a small (1 pellet) or large (2 pellets) reward. In drug-naive controls, core dopamine signals did not discriminate between reward size at any point, while in the shell dopamine encoded magnitude differences only in a slower postpeak period. Despite this lack of discrimination between rewards by the peak DA response, controls easily discriminated between reward options in a subsequent choice task. In contrast, phasic dopamine reward signals were strongly altered by cocaine experience; core dopamine decreased peak response but increased discrimination between reward magnitudes while shell lost phasic responses to reward receipt altogether. Notably, animals with cocaine-associated alterations in dopamine signals for reward magnitude failed to subsequently discriminate between reward options. These findings suggest that cocaine self-administration alters the ability for dopamine signals to appropriately assign value to rewards and thus may in part contribute to later deficits in behaviors that depend on appropriate outcome valuation.

show abstract

Cue-evoked dopamine release in the nucleus accumbens shell tracks reinforcer magnitude during intracranial self-stimulation

Cited by 41 publications

References 39 publications

Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults

Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults

Amylin Modulates the Mesolimbic Dopamine System to Control Energy Balance

Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell

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