Cue-induced resumption of heroin and cocaine seeking in rats using a conflict model of abstinence and relapse

Peck, Joshua A.; Wercberger, Racheli; Kariyeva, Elina; Ranaldi, Robert

doi:10.1007/s00213-013-3069-x

Cited by 19 publications

(14 citation statements)

References 27 publications

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“…Our finding of incubation of methamphetamine craving after punishment extend previous reports in which investigators used response-contingent shock-or shock-barrierbased conflict procedures to study drug relapse induced by exposure to drug priming (Panlilio et al, 2005), drugassociated cues (Cooper et al, 2007;Economidou et al, 2009;Peck et al, 2013), or drug-associated contexts (Marchant et al, 2013a). An unexpected finding was that incubation of food craving after punishment was procedure-dependent and was only observed in the between-subject assessment.…”

Section: Incubation Of Methamphetamine and Food Craving After Punishmentsupporting

confidence: 86%

“…Over the years, several studies have shown that punishment significantly decreases and even eliminates opiate and psychostimulant self-administration (Johanson, 1975;Panlilio et al, 2003;Pelloux et al, 2007;Smith and Davis, 1974). More recently, we and others have begun to use punishment-based procedures to study relapse to drug seeking induced by drug-priming injections (Panlilio et al, 2003;Panlilio et al, 2005) or drug cues and contexts (Cooper et al, 2007;Economidou et al, 2009;Marchant et al, 2013a;Peck et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Krasnova

Marchant

Ladenheim

et al. 2014

Neuropsychopharmacol

115

131

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In a rat model of drug craving and relapse, cue-induced drug seeking progressively increases after withdrawal from methamphetamine and other drugs, a phenomenon termed 'incubation of drug craving'. However, current experimental procedures used to study incubation of drug craving do not incorporate negative consequences of drug use, which is a common factor promoting abstinence in humans. Here, we studied whether incubation of methamphetamine craving is observed after suppression of drug seeking by adverse consequences (punishment). We trained rats to self-administer methamphetamine or palatable food for 9 h per day for 14 days; reward delivery was paired with a tone-light cue. Subsequently, for one group within each reward type, 50% of the lever-presses were punished by mild footshock for 9-10 days, whereas for the other group lever-presses were not punished. Shock intensity was gradually increased over time. Next, we assessed cue-induced reward seeking in 1-h extinction sessions on withdrawal days 2 and 21. Response-contingent punishment suppressed extended-access methamphetamine or food self-administration; surprisingly, food-trained rats showed greater resistance to punishment than methamphetamine-trained rats. During the relapse tests, both punished and unpunished methamphetamine-and food-trained rats showed significantly higher cue-induced reward seeking on withdrawal day 21 than on day 2. These results demonstrate that incubation of both methamphetamine and food craving occur after punishment-induced suppression of methamphetamine or palatable food self-administration. Our procedure can be used to investigate mechanisms of relapse to drug and palatable food seeking under conditions that more closely approximate the human condition.

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Section: Incubation Of Methamphetamine and Food Craving After Punishmentsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Krasnova

Marchant

Ladenheim

et al. 2014

Neuropsychopharmacol

115

131

View full text Add to dashboard Cite

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“…During the electric barrier phase drug was available under a FR2 20-s timeout reinforcement schedule for 30 min/day. This schedule of reinforcement has been used to establish abstinence (no presses on the active lever) without numerous daily sessions that could lead to catheter failure (Cooper et al, 2007;Barnea-Ygael et al, 2012;Peck et al, 2013). Further, the electric barrier current did not exceed 1.00 mA for any individual rat.…”

Section: Electric Barriermentioning

confidence: 99%

“…Recently, we (Peck et al, 2013) used a similar abstinence conflict model with heroin self-administration. We found that abstinence was achieved for all heroin-seeking rats by increasing the electric shock intensity.…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment induces early heroin abstinence in an animal conflict model

Peck

Galaj

Eshak

et al. 2015

Pharmacology Biochemistry and Behavior

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“…Two studies demonstrated relapse to heroin seeking after electric barrier suppression of heroin seeking. Peck et al [136] reported that a higher proportion of heroin-trained rats than cocaine-trained rats resume drug seeking after electric barrier suppression of drug self-administration during a relapse test in which the electric barrier was maintained. For both drugs, the authors observed large individual differences during the relapse tests, most likely because the tests were performed in the presence of the electric barrier.…”

Section: Forced Abstinence and Incubation Of Drug Cravingmentioning

confidence: 99%

Relapse to opioid seeking in rat models: behavior, pharmacology and circuits

Reiner

Fredriksson

Lofaro

et al. 2018

Neuropsychopharmacol

120

101

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Lifetime relapse rates remain a major obstacle in addressing the current opioid crisis. Relapse to opioid use can be modeled in rodent studies where drug self-administration is followed by a period of abstinence and a subsequent test for drug seeking. Abstinence can be achieved through extinction training, forced abstinence, or voluntary abstinence. Voluntary abstinence can be accomplished by introducing adverse consequences of continued drug self-administration (e.g., punishment or electric barrier) or by introducing an alternative nondrug reward in a discrete choice procedure (drug versus palatable food or social interaction). In this review, we first discuss pharmacological and circuit mechanisms of opioid seeking, as assessed in the classical extinctionreinstatement model, where reinstatement is induced by reexposure to the self-administered drug (drug priming), discrete cues, discriminative cues, drug-associated contexts, different forms of stress, or withdrawal states. Next, we discuss pharmacological and circuit mechanisms of relapse after forced or voluntary abstinence, including the phenomenon of "incubation of heroin craving" (the time-dependent increases in heroin seeking during abstinence). We conclude by discussing future directions of preclinical relapse-related studies using opioid drugs.Neuropsychopharmacology (2019) 44:465-477; https://doi.[143] 1Note: Several reinstatement-related papers published results with more than one reinstating stimulus (e.g., drug priming and stress, drug priming and drug cue) and appear in more than one category. Historical citations refer to the initial papers published with a given model.Relapse to opioid seeking in rat models: behavior, pharmacology and. . . DJ Reiner et al.Neuropsychopharmacology (2019) 44:465 -477 1234567890();,:Relapse to opioid seeking in rat models: behavior, pharmacology and. . . DJ Reiner et al.

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Cue-induced resumption of heroin and cocaine seeking in rats using a conflict model of abstinence and relapse

Cited by 19 publications

References 27 publications

Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Environmental enrichment induces early heroin abstinence in an animal conflict model

Relapse to opioid seeking in rat models: behavior, pharmacology and circuits

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