Culcitiolides A-D, Four New Eremophilane-Type Sesquiterpene Derivatives from Senecio Culcitioides

Abstract

Four new eremophilane-type sesquiterpenes, culcitiolides AD , were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor B (NF-B). Culcitiolides C and D at 20 M showed 97 and 100% inhibition of NF-B activity, respectively.

Natural sesquiterpenoids

“…These lactones have been obtained from Senecio culcitioides. 379 The bisnorsesquiterpene paralemnolide A 529 has been found in the Taiwanese so coral Paralemnalia thyrsoides. 380 The role of aristolochene synthase in the activation of diphosphate as leaving group has been studied.…”