Cultivation and Diversity of Marine Actinomycetes: Molecular Approaches and Bioinformatics Tools

Rathore, Dalip Singh; Sharma, Amit Kumar; Dobariya, Ankita; Ramavat, Hashti; Singh, Satya P.

doi:10.1007/978-981-16-5835-8_12

Cited by 4 publications

(1 citation statement)

References 183 publications

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“…Metagenomic studies have given an insight into the evolutionary history, diversity and number of unculturable Actinobacteria, including those from marine habitats [ 65 ]. With the development and advancement of genome sequencing, an immense amount of DNA sequence data are available from public databases.…”

Section: Genomic Insight Of Marine Actinomycetesmentioning

confidence: 99%

Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites

et al. 2022

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Microbial secondary metabolites are an important source of antibiotics currently available for combating drug-resistant pathogens. These important secondary metabolites are produced by various microorganisms, including Actinobacteria. Actinobacteria have a colossal genome with a wide array of genes that code for several bioactive metabolites and enzymes. Numerous studies have reported the isolation and screening of millions of strains of actinomycetes from various habitats for specialized metabolites worldwide. Looking at the extent of the importance of actinomycetes in various fields, corals are highlighted as a potential hotspot for untapped secondary metabolites and new bioactive metabolites. Unfortunately, knowledge about the diversity, distribution and biochemistry of marine actinomycetes compared to hard corals is limited. In this review, we aim to summarize the recent knowledge on the isolation, diversity, distribution and discovery of natural compounds from marine actinomycetes associated with hard corals. A total of 11 new species of actinomycetes, representing nine different families of actinomycetes, were recovered from hard corals during the period from 2007 to 2022. In addition, this study examined a total of 13 new compounds produced by five genera of actinomycetes reported from 2017 to 2022 with antibacterial, antifungal and cytotoxic activities. Coral-derived actinomycetes have different mechanisms of action against their competitors.

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Section: Genomic Insight Of Marine Actinomycetesmentioning

confidence: 99%