Cultivation of the Microalgae Chlorella Pyrenoidosa Using the Processes of Biotechnology

Araújo, Fabíola Ornellas de; Giudici, Reinaldo; Sousa, João

doi:10.25248/reac.e121.2019

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…One g of commercial Spirulina powder supplies up to half of the RDA for β-carotene and vitamin B 12 [ 183 ], with a recommended consumption of less than 4 g per day for an average healthy adult to avoid any toxic effect [ 184 ]. Yet, Chlorella pyrenoidosa powder reduced the risk of anemia, proteinuria and edema in pregnant women [ 185 ] thanks to its high content in thiamine, riboflavin, folic acid, and biotin [ 186 ].…”

Section: Microalgal Vitamins and Human Healthmentioning

confidence: 99%

Challenging microalgal vitamins for human health

et al. 2020

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Background Vitamins’ deficiency in humans is an important threat worldwide and requires solutions. In the concept of natural biofactory for bioactive compounds production, microalgae represent one of the most promising targets filling many biotechnological applications, and allowing the development of an eco-sustainable production of natural bioactive metabolites. Vitamins are probably one of the cutting edges of microalgal diversity compounds. Main text Microalgae can usefully provide many of the required vitamins in humans, more than terrestrial plants, for instance. Indeed, vitamins D and K, little present in many plants or fruits, are instead available from microalgae. The same occurs for some vitamins B (B12, B9, B6), while the other vitamins (A, C, D, E) are also provided by microalgae. This large panel of vitamins diversity in microalgal cells represents an exploitable platform in order to use them as natural vitamins’ producers for human consumption. This study aims to provide an integrative overview on vitamins content in the microalgal realm, and discuss on the great potential of microalgae as sources of different forms of vitamins to be included as functional ingredients in food or nutraceuticals for the human health. We report on the biological roles of vitamins in microalgae, the current knowledge on their modulation by environmental or biological forcing and on the biological activity of the different vitamins in human metabolism and health protection. Conclusion Finally, we critically discuss the challenges for promoting microalgae as a relevant source of vitamins, further enhancing the interests of microalgal “biofactory” for biotechnological applications, such as in nutraceuticals or cosmeceuticals.

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Section: Microalgal Vitamins and Human Healthmentioning

confidence: 99%

Challenging microalgal vitamins for human health

et al. 2020

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“…Tilapia waste was collected from a fish‐processing company in Fortaleza, Brazil. C. vulgaris was obtained from the LDPP‐PADETEC of the Federal University of Ceará (UFC) and cultivated according to Araújo et al 34 with modifications, at the Molecular Biotechnology Laboratory (LabBMol) in the Department of Biochemistry and Molecular Biology at UFC. The experimental protocol for the in vivo healing study was analyzed and approved by the Ethics Committee on Animal Use of the Federal University of Ceará, Campus de Sobral (protocol number 08/19), and comply with the National Council for the Control of Animal Experimentation (CONCEA), Brazil.…”

Section: Methodsmentioning

confidence: 99%

Emulgel based on fish skin collagen‐microalgae‐silver increased neovascularization and re‐epithelialization of full thickness burn in rats

de Souza,

Castro‐Silva,

Andrade

et al. 2024

J Biomed Mater Res

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Deep skin burn represents a global morbidity and mortality problem, and the limitation of topical treatment agents has motivated research to development new formulations capable of preventing infections and accelerating healing. The aim of this work was to develop and characterize an emulgel based on collagen (COL) and gelatin (GEL) extracted from fish skin associated with Chlorella vulgaris extract (CE) and silver nitrate (AgNO3). COL and GEL were characterized by physicochemical and thermal analyses; and CE by electrophoresis and its antioxidant capacity. Three emulgels formulations were developed: COL (0.5%) + GEL (2.5%) (E1), COL+GEL+CE (1%) (E2), and COL+GEL+CE + AgNO3 (0.1%) (E3). All formulations were characterized by physicochemical, rheology assays, and preclinical analyses: cytotoxicity (in vitro) and healing potential using a burn model in rats. COL and GEL showed typical physicochemical characteristics, and CE presented 1.3 mg/mL of proteins and antioxidant activity of 76%. Emulgels presented a coherent physicochemical profile and pseudoplastic behavior. Preclinical analysis showed concentration‐dependent cytotoxicity against fibroblast and keratinocytes. In addition, all emulgels induced similar percentages of wound contraction and complete wound closure in 28 days. The histopathological analysis showed higher scores for polymorphonuclear cells to E1 and greater neovascularization and re‐epithelialization to E3. Then, E3 formulation has potential to improve burn healing, although its use in a clinical setting requires further studies.

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Cultivation of the Microalgae Chlorella Pyrenoidosa Using the Processes of Biotechnology

Cited by 2 publications

References 11 publications

Challenging microalgal vitamins for human health

Challenging microalgal vitamins for human health

Emulgel based on fish skin collagen‐microalgae‐silver increased neovascularization and re‐epithelialization of full thickness burn in rats

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