Cultivation of Viruses From a High Proportion of Patients With Colds

Tyrrell, D. A. J.; Bynoe, M. L.

doi:10.1016/s0140-6736(66)92364-6

Cited by 367 publications

(270 citation statements)

References 1 publication

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“…Another, less likely explanation is that currently unrecognized agents or noncultivable agents are more prevalent in older age groups. This might partially be the case, since non-cultivable rhinoviruses and all coronaviruses could not have been recovered with techniques used [27,28]. These agents are proportionally more likely to be involved in illnesses of older than younger individuals.…”

Section: Discussionmentioning

confidence: 99%

Acute respiratory illness in the community. Frequency of illness and the agents involved

1993

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SUMIMIARYInvestigations of respiratory illnesses and infections in Tecumseh, Michigan, USA, were carried out in two phases, together covering 11 years. During the second phase. there were 5363 person-years of observation. Respiratory illness rates in both males and females peaked in the 1-2 year age group and fell thereafter. Adult females had more frequent illnesses than adult males; illnesses were less common in working women than in women not working outside the home. Isolation of viruses fell with increasing age; rhinoviruses were the most common isolate. Influenza infection rates, determined serologically, suggested relative sparing of young children from infection with type A (HiN1) and type B. Infection rates were highest in adult age groups for type A (H3N2). The isolation and serological infection rates were used to estimate the extent to which laboratory procedures underestimated the proportion of respiratory illnesses caused by each infectious agent; data from other studies were also used in this estimation. Severity of respiratory illnesses was assessed by the proportion of such illnesses that resulted in consultation of a physician. Rhinoviruses produced the greatest number of consultations. Overall, physician consultations were associated with 25-4 % of respiratory illnesses.

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Section: Discussionmentioning

confidence: 99%

Acute respiratory illness in the community. Frequency of illness and the agents involved

1993

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“…There is a close similarity between the proportion of patients admitted and those treated as out-patients, the range and mean duration of time off duty for rhinovirus infections, and for those where no agent was isolated. (Higgins, 1966a) are confirmed, as are the advantages of employing organ cultures of ciliated epithelium when attempting to detect these viruses (Tyrrell & Bynoe, 1966;Higgins, 1966b).…”

Section: Association Of Virus With Clinical Illnessmentioning

confidence: 93%

Viruses associated with acute respiratory infections in Royal Air Force personnel

Higgins¹,

Ellis²,

Woolley³

et al. 1970

Epidemiol. Infect.

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SUMMARYAll respiratory illnesses which were reported to the medical officers between September 1966 and December 1967 on a Royal Air Force station of 350 men were studied virologically.Three periods of increased respiratory infections were observed: two occurred in the autumn, one in each year, and the third in the winter during January and February. The autumnal outbreaks were associated mainly with rhinovirus infections, and high isolation rates (82.1, 65-9 00) were achieved at these times. Few of the illnesses during the winter outbreak could be diagnosed in the laboratory, and no evidence was found of infection with 'coronaviruses'.Despite the entrance of 30 fresh recruits direct from civilian life every 5 weeks, the respiratory infections encountered on the station were very similar to those in the local population and were not predominantly infections with adenoviruses, Coevirus, and Mycoplasma pneumoniae, as previously reported from larger military recruit centres.

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“…This situation is analogous to the diagnosis of rhinovirus infections where many more infections can be diagnosed by the additional use of organ cultures of ciliated respiratory epithelium than by the inoculation of tissue cultures alone (Tyrrell and Bynoe, 1966;Higgins, 1966). Because of the similarity in the pattern of isolation of these enteroviruses and the rhinoviruses it would be expected that some strains of enterovirus will be detected in tissue culture and not in organ cultures as is known to occur with the rhinoviruses (Higgins, Ellis, and Woolley, 1969).…”

Section: Discussionmentioning

confidence: 99%

The isolation of enteroviruses from cases of acute conjunctivitis

Higgins¹,

Scott²

1973

J Clin Pathol

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SYNOPSIS In two epidemics of acute enterovirus conjunctivitis the diagnosis could only be established by the use of human embryonic organ cultures. In one instance cultures of ciliated respiratory epithelium proved sensitive to the virus but similar culture failed to support growth of the virus from the second outbreak which was isolated in organ cultures of conjunctiva.The virus associated with a third outbreak had previously been isolated from the original material by culture in human embryo kidney cells, but it required passage in organ culture for its detection after the specimens had been diluted.

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Cultivation of Viruses From a High Proportion of Patients With Colds

Cited by 367 publications

References 1 publication

Acute respiratory illness in the community. Frequency of illness and the agents involved

Acute respiratory illness in the community. Frequency of illness and the agents involved

Viruses associated with acute respiratory infections in Royal Air Force personnel

The isolation of enteroviruses from cases of acute conjunctivitis

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