Cultivation Stress Techniques and the Production of Secondary Metabolites in Cannabis sativa

Seaman, Callie

doi:10.1201/9780429274893-1

Cited by 2 publications

(2 citation statements)

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“…This makes mechanism of action assays notoriously difficult as the effects could be attributable to a variety of compounds. Despite these challenges, botanical medicines can be developed in this way ( 12 ).…”

Section: Limitations Of Randomised Controlled Trialsmentioning

confidence: 99%

The value of real world evidence: The case of medical cannabis

Schlag

Zafar

Lynskey³

et al. 2022

Front. Psychiatry

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Randomised controlled trials (RCTs) have long been considered the gold standard of medical evidence. In relation to cannabis based medicinal products (CBMPs), this focus on RCTs has led to very restrictive guidelines in the UK, which are limiting patient access. There is general agreement that RCT evidence in relation to CBPMs is insufficient at present. As well as commercial reasons, a major problem is that RCTs do not lend themselves well to the study of whole plant medicines. One solution to this challenge is the use of real world evidence (RWE) with patient reported outcomes (PROs) to widen the evidence base. Such data increasingly highlights the positive impact medical cannabis can have on patients’ lives. This paper outlines the value of this approach which involves the study of interventions and patients longitudinally under medical care. In relation to CBMPs, RWE has a broad range of advantages. These include the study of larger groups of patients, the use of a broader range and ratio of components of CBMPs, and the inclusion of more and rarer medical conditions. Importantly, and in contrast to RCTs, patients with significant comorbidities–and from a wider demographic profile–can also be studied, so providing higher ecological validity and increasing patient numbers, whilst offering significant cost savings. We conclude by outlining 12 key recommendations of the value of RWE in relation to medical cannabis. We hope that this paper will help policymakers and prescribers understand the importance of RWE in relation to medical cannabis and help them develop approaches to overcome the current situation which is detrimental to patients.

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Section: Limitations Of Randomised Controlled Trialsmentioning

confidence: 99%

The value of real world evidence: The case of medical cannabis

Schlag

Zafar

Lynskey³

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

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“…Because of large variability within cultivars, significant differences in height between cultivars were only observed between 'Fedora17' and 'Finola' (Tukey's HSD, p = 0.039, Fig 2a). Hemp biomass is an important factor for multiple applications, including secondary metabolites extraction (43,44), phytoremediation, and bioethanol production (45), as well as for calculating the carbon sequestration capacity (46). In the hemp plants cultivated, aboveground fresh biomass yield varied almost ten-fold between individuals of the same cultivar, with a mean of 230 g over all cultivars (Fig 2b, Table 1, S1 Table ).…”

Section: Resultsmentioning

confidence: 99%

Exploring phenotypic and genetic variability in hemp (Cannabis sativa)

Trubanová,

Pender,

McCabe

et al. 2023

Preprint

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Hemp (Cannabis sativaL.) is a high-value multi-purpose crop with applications ranging from the medicinal use of its secondary metabolites to carbon-sequestering building materials. To fully capitalise on the potential of hemp as a crop for more sustainable agriculture, detailed phenotypic and genotypic characterizations are required in order to inform targeted breeding programmes.Here, we present a detailed morphological and genomic analysis of 10 hemp cultivars. We found high variability in agronomically important traits such as flowering time, plant height, and biomass in most of the hemp cultivars tested. Additionally, genotyping by sequencing demonstrates that genetic differences are pervasive, both between hemp cultivars as well as between individuals of a single cultivar. The significant genetic and phenotypic variability we observe in hemp contrasts with other crops, where cultivars are often phenotypically and genetically relatively uniform. We argue that the variability of hemp is an asset for breeding and increases the potential for further improvement of the crop but is also a challenge for today’s highly automated agriculture that relies on phenotypic uniformity.Author summaryHemp (Cannabis sativaL.) stands as one of the earliest domesticated crops. This remarkable plant is a sustainable crop with high carbon sequestration capacity which can be cultivated for soil remediation. Furthermore, hemp oil and fibre are used for many applications ranging from cooking to manufacturing bioplastics, textiles, or building materials of superb characteristics, and its secondary metabolites are sought after because of their medicinal properties. However, in contrast to many modern crops, hemp exhibits extensive variability in key agricultural traits, such as plant height and flowering time. This variability presents a challenge for both farmers and processors. To unravel the fundamentals of hemp diversity we conducted a comprehensive study of phenotypic and genetic characterisation of ten diverse hemp cultivars. We present findings confirming substantial variability not only among individuals of different cultivars but also within the same cultivar. Additionally, we explore heterozygosity in the context of other hemp studies and other crops. Understanding this variability in the context of a single hemp cultivar and across multiple cultivars is paramount for breeding novel, more uniform hemp varieties which will allow us to unlock the full potential of hemp as a crop of the future.

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Cultivation Stress Techniques and the Production of Secondary Metabolites in Cannabis sativa

Cited by 2 publications

References 0 publications

The value of real world evidence: The case of medical cannabis

The value of real world evidence: The case of medical cannabis

Exploring phenotypic and genetic variability in hemp (Cannabis sativa)

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