Chronic urticaria is a popular skin complaint that is characterized by wheals of various sizes surrounded by erythema and associated with itching and burning as a consequence of Type1 hypersensitivity reaction mediated by IgE antibodies to specific allergen. Most of the population (>20%) have urticaria once somewhere in the life. The conventional management of this condition is associated with long-term effects of anti-allergic drugs and inexorable recurrence. Homoeopathic medicines help to reduce the hypersensitivity and recurrence in a gentle and permanent way. The present study is done to assess the effect of homoeopathic medicine in case of chronic urticaria. Case Summary: The below mentioned case is related to Cholinergic urticaria, one of the types of Physical urticaria in a young male who was given Psorinum as an Individualized prescription. The change in the assessment score done by UAS7 Urticaria Activity Score which was 42 at the baseline and 2 at the end of the treatment. MYMOP2 Measure Yourself Medical Outcome Profile 2 was 4.5 and after treatment was 1. The reduction in the assessment score reveals a significant improvement in the disease and quality of life. Serum IgE levels at the beginning of treatment was 367 IU/ml reduced to 112 IU/ml, which shows a significant curative effect on the patient. Thus, Homoeopathy proved to be efficacious in the treatment of chronic urticarial and in improving quality of life.