Cultural characteristics of malignant histiocytomas and fibrous xanthomas

Ozzello, Luciano; Stout, Arthur Purdy; Murray, Margaret R.

doi:10.1002/1097-0142(196303)16:3<331::aid-cncr2820160307>3.0.co;2-f

Cited by 502 publications

(136 citation statements)

References 18 publications

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“…The term was first introduced in 1963 to refer to a group of soft tissue tumors characterized by a storiform or cartwheel-like growth pattern, which were believed to be derived from histiocytes on the basis of early tissue culture studies demonstrating ameboid movement and phagocytosis of explanted tumor cells. 1,2 However, ultrastructural studies both endorsed and refuted the histiocytic origin of these tumors. With the advent of immunohistochemistry and the accessibility of numerous monoclonal antibodies directed against various structural proteins of specific cell types, the phenotype of this tumor was shown to be more closely aligned with a fibroblast than a histiocyte.…”

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confidence: 99%

An approach to pleomorphic sarcomas: can we subclassify, and does it matter?

Goldblum

2014

Modern Pathology

101

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The term malignant fibrous histiocytoma (MFH) has been supplanted by undifferentiated pleomorphic sarcoma (UPS). Even now, however, a number of pleomorphic neoplasms are classified as UPSs when in fact at least a subgroup of these can be more precisely classified as a pleomorphic sarcoma with a specific line of differentiation. Still others are pseudosarcomas, most commonly sarcomatoid carcinomas. This review will discuss historical aspects of MFH/UPS as well as provide an approach to the pleomorphic malignant neoplasm with a discussion of useful ancillary techniques in the evaluation of such cases.

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confidence: 99%

An approach to pleomorphic sarcomas: can we subclassify, and does it matter?

Goldblum

2014

Modern Pathology

101

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“…6 The tumors now defined as pleomorphic dermal sarcomas have also been referred to as cutaneous undifferentiated pleomorphic sarcomas, and in the past as superficial malignant fibrous histiocytomas. [7][8][9] There are currently no effective therapies for metastasized pleomorphic dermal sarcomas.…”

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confidence: 99%

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas

et al. 2014

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Activating mutations in the TERT promoter leading to increased telomerase expression were recently identified in cutaneous melanoma and subsequently in many other types of cancer. These mutations lead to increased telomerase expression, allowing cells to proliferate continuously without entering apoptosis or senescence. Atypical fibroxanthomas and pleomorphic dermal sarcomas are genetically poorly understood tumors developing in the skin of older patients. Known genetic events in these tumors are mutations in TP53 (atypical fibroxanthoma and pleomorphic dermal sarcoma) and RAS (pleomorphic dermal sarcoma) genes, often having a UV signature. We analyzed a cohort of 27 atypical fibroxanthomas and 34 pleomorphic dermal sarcomas for the presence of TERT promoter mutations by conventional Sanger sequencing. TERT promoter mutations were identified in 25 (93%) atypical fibroxanthomas and in 26 (76%) pleomorphic dermal sarcomas. Mutations were found to have a UV signature (C4T or CC4TT) and were largely identical to those detected in cutaneous melanoma. Our data show that TERT promoter mutations are the most frequent mutations in atypical fibroxanthomas and pleomorphic dermal sarcomas reported to date. The identified mutations confirm the pathogenetic role of UV exposure in both atypical fibroxanthomas and pleomorphic dermal sarcomas and suggest that telomere maintenance through increased expression of telomerase plays an important role in the pathogenesis of these tumors.

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“…MFH was first described in 1963 by Ozello et al and was established by O'Brien and Stout in 1964, which refers to a group of soft tissue sarcoma composed of both histiocytic and fibrous elements, often has some common features, www.wjgnet.com such as pleomorphism and storiform pattern of growth and is accompanied by inflammatory cells [24,25] . The most frequent site of MFH is the deep tissue of the extremities and trunk.…”

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confidence: 99%