Following the hype that has been given to culture as trigger and enhancer of local economic performance in the last 20 years, the cultural character of cities is considered as a strategic strength and opportunity that can favour the economic system of the entire regions in which the cities are located. According to this perspective, this paper explores the role of cultural participation, intended as individuals' involvement in cultural activities, in affecting regional output. Exploiting a regional production function and data from the Cultural and Creative Cities Monitor (CCCM) provided by the European Commission Joint Research Centre (JRC), the effect of urban cultural participation on the regional economy is econometrically investigated. Potential congestion effects possibly related to (excessive) cultural tourism are also examined. Cultural participation in Cultural and Creative Cities emerges as a strategic resource for development, although some congestion mechanisms could reduce its positive effect. Related policy implications are thoroughly discussed.