Objective: To explore the effect of anxiety, depression and hypertension
on quality of life (QOL) of patients with gynecological tumor and the
interaction among them, and the moderating effect of social support.
Design: Cross-sectional design Setting: December 2019 to July 2020, the
COVID-19 outbreak phase. Population or Sample: A total of 695
gynecological cancer patients were collected. Methods: The study used
the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale
(SDS), the Functional Assessment of Cancer Therapy Genera tool (FACT-G),
and the Multidimensional Scale of Perceived Social Support Scale
(MSPSS). Regression analysis and the simple slope analysis were
conducted. Results: QOL of patients with anxiety and hypertension had
seriously deteriorated [OR=10.297, 95%CI (5.647-18.775)]. And QOL
of patients with depression and hypertension also had seriously
deteriorated [OR=11.846, 95%CI (6.597-21.271)]. Calculated by
crossover analysis, the synergy index, attributable proportion and
relative excess risk due to interact of anxiety and hypertension
were1.698,0.371 and 3.822, and the correlation index of interaction
between depression and hypertension were 1.475, 0.295, and 3.493. The
Social Support &Depression interaction term and Social Support
&Anxiety interaction term were negatively correlated with QOL
(p<0.01), and explained an extra 5.7% and 5.6% of the
variance respectively (p<0.01). Conclusion: Anxiety,
depression and hypertension have interaction on the QOL of patients with
gynecological tumors. Social support can significantly moderate the
relationship between depression, anxiety and QOL respectively. Funding:
National Key R&D Program of China (Grant #2018YFC1311600). Keywords:
quality of life, depression, anxiety, social support, hypertension,
moderating effect