This paper provides readers with an overview of the unique issues present in secondary classrooms and their impact on the practice of collaborative teaching between general and special educators. The authors focus on the changes that are occurring in secondary classrooms related to varied structures (such as block scheduling), higher standards, high stakes testing, a more diverse society, and how co-teaching can better address these issues. Readers are provided with practical strategies to enhance the effectiveness of teachers working together as well as tips to avoid the potential pitfalls when teaming at the secondary level.Co-teaching (sometimes known as collaborative or cooperative teaching, team teaching, or even teaming) is an educational practice currently being discussed in most schools across the nation. This practice is increasingly observed at the secondary level as a potential method of addressing the inclusive movement. Whatever the name, many educators look to co-teaching with a colleague in anticipation, while an equal number fear or even dread the thought.This new trend in service delivery between general and special education is being embraced at all levels. However, constraints on collaboration between educators are compounded at the secondary level. This separation of general and special education begins with the structure at the university level and continues into the structure imposed in many school settings. The purpose of this article is to recognize these constraints and to suggest strategies related to the content, structure and increasing diversity of today's classrooms when attempting to employ a co-teaching model at the secondary level.