Cultural factors related to neuropsychological performance and brain atrophy among Hispanic older adults with amnestic Mild Cognitive Impairment (aMCI): A pilot study

Rodriguez, Miriam J.; Mendoza, Lisandra; Rosselli, Mónica; Loewenstein, David; Burke, Shanna L.; Orozco, Amanda; Duara, Ranjan

doi:10.1080/23279095.2020.1761368

Cited by 9 publications

(3 citation statements)

References 82 publications

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“…Fourth, we did not test the association of brain measures with cognitive outcomes although we did conduct a sensitivity analysis excluding those with mild cognitive impairment ( Dong et al, 2015 ; Fletcher et al, 2018 ). Fifth, we did not test for modification by social determinants of health (e.g., access to insurance, literacy; Rodriguez et al, 2022 ; Sadhu et al, 2019 ) which may point to potential modifiable factors related to brain aging. Further work will more completely address these issues.…”

Section: Discussionmentioning

confidence: 99%

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Stickel

Tarraf

González

et al. 2023

Neurobiology of Aging

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Section: Discussionmentioning

confidence: 99%

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Stickel

Tarraf

González

et al. 2023

Neurobiology of Aging

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“…It has been hypothesized that culturally-specific factors (e.g., dietary habits, exposure to distinct risk factors, health care quality and accessibility) may influence the progression of neurodegenerative diseases and cognitive decline more generally (Rodriguez et al, 2022; Sheng et al, 2022). However, previous dFC studies have mainly been conducted on culturally homogenous samples (Tian et al, 2018; Viviano et al, 2017; Xia et al, 2019; Zhang et al, 2021b), raising doubts about the universality of age-related dFC changes.…”

Section: Discussionmentioning

confidence: 99%

Age-dependent changes in the dynamic functional organization of the brain at rest – a cross-cultural replication approach

Yang¹,

Zhou

Xin

et al. 2022

Preprint

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Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity (FC), accumulating evidence suggests that advancing age is especially associated with alterations in the dynamic interactions and transitions between different brain states, which hitherto has received less attention. Moreover, conclusions of previous studies in this domain are limited by suboptimal replicability of resting state fMRI and culturally homogenous cohorts. Here, we investigate the robustness of age-associated changes in dynamic functional connectivity (dFC) by capitalizing on the availability of fMRI cohorts from two cultures (Western European and Chinese). In both cohorts we consistently identify two distinct connectivity states: a more frequent segregated within-network connectivity state (state I) and a less frequent integrated between-network connectivity state (state II). In both cohorts, older (55-80 years) compared to younger participants (20-35 years) exhibited lower occurrence of and spent less time in state I. Moreover, older participants tended to exhibit more transitions between networks and greater variance in global efficiency. Overall, our cross-cultural replication of age-associated changes in key dFC metrics implies that advancing age is robustly associated with a reorganization of dynamic brain activation that favors the use of less functionally-specific networks.

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“…It has been hypothesized that culturally specific factors (e.g. dietary habits, exposure to distinct risk factors, healthcare quality and accessibility) may influence the progression of neurodegenerative diseases and cognitive decline more generally ( Rodriguez et al. 2022 ; Sheng et al.…”

Section: Discussionmentioning

confidence: 99%

Age-dependent changes in the dynamic functional organization of the brain at rest: a cross-cultural replication approach

et al. 2023

View full text Add to dashboard Cite

Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity, accumulating evidence suggests that advancing age is especially associated with alterations in the dynamic interactions and transitions between different brain states, which hitherto have received less attention. Conclusions of previous studies in this domain are moreover limited by suboptimal replicability of resting-state functional magnetic resonance imaging (fMRI) and culturally homogenous cohorts. Here, we investigate the robustness of age-associated changes in dynamic functional connectivity (dFC) by capitalizing on the availability of fMRI cohorts from two cultures (Western European and Chinese). In both the LEMON (Western European) and SALD (Chinese) cohorts, we consistently identify two distinct states: a more frequent segregated within-network connectivity state (state I) and a less frequent integrated between-network connectivity state (state II). Moreover, in both these cohorts, older (55–80 years) compared to younger participants (20–35 years) exhibited lower occurrence of and spent less time in state I. Older participants also tended to exhibit more transitions between networks and greater variance in global efficiency. Overall, our cross-cultural replication of age-associated changes in dFC metrics implies that advancing age is robustly associated with a reorganization of dynamic brain activation that favors the use of less functionally specific networks.

show abstract

Cultural factors related to neuropsychological performance and brain atrophy among Hispanic older adults with amnestic Mild Cognitive Impairment (aMCI): A pilot study

Cited by 9 publications

References 82 publications

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Age-dependent changes in the dynamic functional organization of the brain at rest – a cross-cultural replication approach

Age-dependent changes in the dynamic functional organization of the brain at rest: a cross-cultural replication approach

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