Cultural Impact on Medication Instructions: The Case of the Turkish Teaspoon

Kannan, Lakshmi; Blocher, Nissa

doi:10.1097/pts.0000000000000175

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…The formulation of effervescent granules of MA 001 into fixed dose sachets was undertaken to address issues such as inaccurate dosing resulting from differences in volumes of household spoons used in drug administration [10,20,21], patient convenience and compliance. Patient convenience and compliance are critical for effective treatment outcomes in the management of microbial infections [22,23,24].…”

Section: Discussionmentioning

confidence: 99%

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Adi-Dako

Kumadoh

Egbi

et al. 2021

Heliyon

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Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drugresistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis. The findings indicate that the effervescent granules were suitable for use in the delivery of the therapeutic constituents for the treatment of typhoid fever as done with the decoction due to minimal herbal extract-excipient interaction.

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