Culture-proven endogenous endophthalmitis: clinical features and visual acuity outcomes

Schiedler, Vivian; Scott, Ingrid U.; Flynn, Harry W.; Davis, Janet L.; Benz, Matthew S.; Miller, Darlene

doi:10.1016/j.ajo.2003.11.013

Cited by 154 publications

(222 citation statements)

References 11 publications

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“…Previous studies, primarily from Asia, 9,10,15 found liver abscess was the most common infective source in their cohorts with Klebsiella pneumoniae, the most frequent causative organism. Schiedler et al 16 demonstrated, in his series from the USA, a more frequent fungal aetiology with 62% of cases positive for Candida albicans. Similarly, Qiong-Yan Zhang et al 17 demonstrated a 63% fungal aetiology in their series of EE.…”

Section: Discussionmentioning

confidence: 99%

Endogenous endophthalmitis: 10-year experience at a tertiary referral centre

Connell

O'Neill

Fabinyi

et al. 2010

Eye

208

153

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Purpose Endogenous endophthalmitis (EE) is a sight-threatening emergency and the aetiology is often multifactorial. Delayed diagnosis may exacerbate the poor visual prognosis. We describe the management and visual outcomes of EE presenting to a tertiary referral centre. Patients and methods A prospective consecutive case series of 64 patients presenting with presumed EE from 1997 to 2007 to the Royal Victorian Eye and Ear Hospital were included. All data were collected in a standardized manner. Outcome measures included: visual acuity, microbial profiles, and vitrectomy rate. Results In total, 64 cases of EE were identified over the study period with a mean age of 57.5 years, and 53.5% were male. Presenting acuities ranged from Snellen 6/6 to no perception of light (NPL). Identifiable risk factors were present in 78.1%, with the majority related to intravenous drug abuse. A 64.1% culture positivity rate was recorded. A vitrectomy rate of 57, 56, and 21% was recorded in documented bacterial, fungal, and no growth cases, respectively. Final Snellen acuities ranged from 6/6 to NPL. A total of 5 out of 64 eyes were enucleated, of which 3 identified Klebsiella species. Better visual outcome was documented in fungal cases. Conclusion EE is a serious ocular condition and has a varied aetiology. Visual outcomes are often poor, irrespective of the method of management. Fungal aetiology often confers a better prognosis, and vitrectomy is advocated for bacterial proven cases.

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Section: Discussionmentioning

confidence: 99%

Endogenous endophthalmitis: 10-year experience at a tertiary referral centre

Connell

O'Neill

Fabinyi

et al. 2010

Eye

208

153

View full text Add to dashboard Cite

show abstract

“…De hecho, en nuestra serie la VPP se practicó en los casos más agresivos, (casos 3, 8 y 9), alcanzando una AV final > 0,1 en dos de los tres casos. Por esta razón, se justifica la realización de VPP precoz en las endoftalmitis fúngicas, cuya evolución suele ser más tórpida que las bacterianas 5,8 . El caso 3, paciente UDVP y alcohólico, con endoftalmitis candidiásica, no quiso seguir tratamiento ocular alguno ni someterse a cirugía hasta un mes después del diagnóstico de la infección, presentando diversas complicaciones que derivaron en amaurosis.…”

Section: Discussionunclassified

Endoftalmitis endógenas: revisión de una serie de casos y revaloración de una entidad ocular grave

Asencio-Egea¹,

Huertas-Vaquero²,

Carranza-González³

et al. 2013

Rev. chil. infectol.

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“…In different published series, fungal organisms account for more than half of the cases of endogenous endophthalmitis in which candida albicans is the most frequent cause (75-80%) and in our study fungal organism was found in 4 cases out of 8 culture-positive cases, in which 3 (75%) cases were of candida. [5] Debate exists over the intraocular aspiration / biopsy of endogenous endophthalmitis. Blood, urine, cerebrospinal fluid, complete blood count with differential (evaluating for signs of infection, elevated white count), (erythrocyte sedimentation rate (evaluating for rheumatic causes, chronic infections or malignancy), blood urea nitrogen (evaluating for renal failure or patients at increased risk), wound culture and smear may be indicated to locate the original infection and document systemic involvement.…”

Section: Evaluation Of Outcome Of Various Treatment Methodsmentioning

confidence: 99%

“…Blood culture was done thrice in all cases. [5] Aqueous and vitreous cultures were also done whenever possible by an ophthalmic surgeon; sterile needles were used to aspirate material. Because of the small amounts of material involved, inoculation of plates and preparation of slides were done at the patient's side.…”

Section: Methodsmentioning

confidence: 99%