2022
DOI: 10.1111/joa.13719
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Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport

Abstract: Small and large animal models are important tools for investigating the pathogenesis of neurodegenerative diseases and developing therapeutic strategies, particularly when diseases are species-specific. Horses are affected by various neuropathies, including the highly prevalent recurrent laryngeal neuropathy (RLN) of large breeds (Draper & Piercy, 2018), sensory disorders, such as equine trigeminal-mediated head shaking syndrome (Aleman et al., 2013) and autonomic dysfunction seen in equine grass sickness (Cot… Show more

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Cited by 5 publications
(5 citation statements)
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“…Stem cell technologies have emerged over the last two decades to create a field with much promise for generating therapeutics and cellular regenerative biology insights for chronic degenerative disorders (Zakrzewski et al, 2019). Insights into the physiological and pathological function of the NMJ might come from iPSC-derived models (Thompson et al, 2012;Lin et al,2019), or cultured neurons, which have now been generated from large mammals (Pessôa et al, 2019;Bressan et al, 2020), including horses (Adalbert et al, 2022).…”
Section: The Promise and Practice Of Stem Cell Workmentioning
confidence: 99%
See 1 more Smart Citation
“…Stem cell technologies have emerged over the last two decades to create a field with much promise for generating therapeutics and cellular regenerative biology insights for chronic degenerative disorders (Zakrzewski et al, 2019). Insights into the physiological and pathological function of the NMJ might come from iPSC-derived models (Thompson et al, 2012;Lin et al,2019), or cultured neurons, which have now been generated from large mammals (Pessôa et al, 2019;Bressan et al, 2020), including horses (Adalbert et al, 2022).…”
Section: The Promise and Practice Of Stem Cell Workmentioning
confidence: 99%
“…Stem cell technologies have emerged over the last two decades to create a field with much promise for generating therapeutics and cellular regenerative biology insights for chronic degenerative disorders (Zakrzewski et al, 2019 ). Insights into the physiological and pathological function of the NMJ might come from iPSC‐derived models (Lin et al, 2019 ; Thompson et al, 2012 ), or cultured neurons, which have now been generated from large mammals (Bressan et al, 2020 ; Pessôa et al, 2019 ), including horses (Adalbert et al, 2022 ). iPSCs can be differentiated into muscle or neural tissue, with a future promise of in vitro NMJ models (Jongh et al, 2021 ), providing an understanding of the cellular and molecular mechanism and the aetiology underlying many NMJ‐related disorders and peripheral neuropathies.…”
Section: The Promise and Practice Of Stem Cell Workmentioning
confidence: 99%
“…The current study reported that the PGN cell body diameter in camel CCG ranges from 78 to 251μm which indicates that its size is larger than those of horse, dog and cat (Fioretto et al 2007). It has also been reported to be larger than dorsal root ganglia when compared with the findings in the horse (Adalbert et al 2022), bovine (Fadda et al 2016) and humans (Valtcheva et al 2016). The latter two authors claimed that large neuronal size could reflect very long axons they have to support.…”
Section: Discussionmentioning
confidence: 87%
“…Continuing the theme of using diverse models to study PNS function and dysfunction, Adalbert et al describe experiments in which they dissociated and cultured primary sensory neurons from dorsal root ganglia (DRG) of adult horses (Adalbert et al, 2022). Mixed sensory neuronal populations were viable for at least 3 months and shown to develop long neurites, which were used to study mitochondrial morphology and trafficking.…”
Section: Dominant Intermediate Cmt Type C (Di-cmtc) Is a Geneticmentioning
confidence: 99%