2003
DOI: 10.1080/03008200390200210
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Cultures of Ligament Fibroblasts in Fibrin Matrix Gel

Abstract: The cellular properties of anterior cruciate ligament (ACL) and medial collateral ligament (MCL) fibroblasts have been analyzed in a three-dimensional fibrin matrix gel (FMG) system. The MCL fibroblasts proliferated significantly faster than ACL fibroblasts in 10% fetal bovine serum (FBS). FMG contraction resembles soft-tissue wound contraction. Transforming growth factor-beta1 (TGF-beta1) (5 ng/ml) caused a significantly faster rate of FMG contraction than control (0.5% FBS) in both ACL and MCL fibroblasts. U… Show more

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Cited by 17 publications
(19 citation statements)
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“…Specifically, fibroblasts migrating from MCL explants in vitro migrate faster in comparison to ACL fibroblasts [19,25,47]. Differences in migration rates and ECM gene expression and production between MCL and ACL fibroblasts have been confirmed in various species [4,14,15,19,25,30,37,47,53]. These observations support the premise that enhanced cellular properties contribute to greater healing capacity.…”
Section: Introductionsupporting
confidence: 55%
“…Specifically, fibroblasts migrating from MCL explants in vitro migrate faster in comparison to ACL fibroblasts [19,25,47]. Differences in migration rates and ECM gene expression and production between MCL and ACL fibroblasts have been confirmed in various species [4,14,15,19,25,30,37,47,53]. These observations support the premise that enhanced cellular properties contribute to greater healing capacity.…”
Section: Introductionsupporting
confidence: 55%
“…Similarly, ligament fibroblasts encapsulated in fibrin gels have been shown to proliferate, contract the gel and secrete ECM (Chun et al 2003).…”
Section: Ligament and Tendonmentioning
confidence: 99%
“…The blended alginate-fibrin hydrogel demonstrated improved toughness and resistance to cell mediated contraction. It has previously been shown that growth factors can stimulate contraction of cell-seeded fibrin gels (Chun et al, 2003;Montesano and Orci, 1988) in vitro as well as granulation tissue in vivo (Desmouliere et al, 1993). Alginate is more dimensionally stable than fibrin but is also more brittle and prone to tearing (Kim et al, 2011).…”
Section: Discussionmentioning
confidence: 99%