Cumulative and noncumulative dose-response curves to noradrenaline on the dorsal hand vein

Abdelmawla, A. H.; Langley, R. W.; Szabadi, E.; Bradshaw, C. M.

doi:10.1016/s1056-8719(96)00077-9

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Cited by 2 publications

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The Safe Dose in the Utilization of Chemicals

Ishido

2023

Health Risk Assessment of Environmental Chemicals

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The Safe Dose in the Utilization of Chemicals

Ishido

2023

Health Risk Assessment of Environmental Chemicals

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Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline‐ and methoxamine‐evoked constriction of the dorsal hand vein

Szabadi

et al. 1999

Brit J Clinical Pharma

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Aims To examine whether the antidepressant venlafaxine, a novel serotoninnoradrenaline re-uptake inhibitor (SNRI), can modify a-adrenoceptor-mediated venoconstriction in man. The effects of venlafaxine were compared with those of desipramine, a tricyclic antidepressant with noradrenaline uptake inhibiting properties, and paroxetine, a selective serotonin re-uptake inhibitor (SSRI), on noradrenalineand methoxamine-evoked venoconstriction using the dorsal hand vein compliance technique. Methods Fifteen healthy male volunteers participated in five weekly experimental sessions. Each session was associated with a clinically effective dose of an antidepressant or placebo. The following oral dosages were used: venlafaxine 75 mg, venlafaxine 150 mg, desipramine 100 mg, paroxetine 20 mg, or placebo. A doubleblind, cross-over, balanced design was used. In each session, dose-response curves to both locally infused noradrenaline acid tartrate (0.1-33.33 ng min Conclusions These results show that, similarly to desipramine 100 mg, venlafaxine 150 mg can potentiate venoconstrictor responses to noradrenaline, consistent with venlafaxine's ability to block noradrenaline uptake in man. The importance of noradrenaline uptake blockade in these observations is confirmed by the lack of effect of the antidepressants on methoxamine-evoked venoconstriction and the failure of paroxetine to modify noradrenaline-evoked venoconstriction.

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Cumulative and noncumulative dose-response curves to noradrenaline on the dorsal hand vein

Cited by 2 publications

References 9 publications

The Safe Dose in the Utilization of Chemicals

The Safe Dose in the Utilization of Chemicals

Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline‐ and methoxamine‐evoked constriction of the dorsal hand vein

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