2020
DOI: 10.1161/circulationaha.119.042502
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Cumulative Blood Pressure Exposure During Young Adulthood and Mobility and Cognitive Function in Midlife

Abstract: Background: High blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife. Furthermore, we tested whether these associations were modified by cerebral white matter hyperintensity (WMH) burden. Methods: We included 191 participants from the CARDIA study (Coronary Artery Risk Devel… Show more

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Cited by 86 publications
(78 citation statements)
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“…Fifty-two studies ( n = 343,794, weighted mean age (MWA) = 58.7 years, women = 53.2%) met the inclusion criteria presented in Supplementary Information; Table S2 . They included 33 cross-sectional [ 5 , 6 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ] and 26 longitudinal studies [ 5 , 28 , 39 , 41 , 45 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ] with follow-up ranging from ~2 [ 39 , ...…”
Section: Resultsmentioning
confidence: 99%
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“…Fifty-two studies ( n = 343,794, weighted mean age (MWA) = 58.7 years, women = 53.2%) met the inclusion criteria presented in Supplementary Information; Table S2 . They included 33 cross-sectional [ 5 , 6 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ] and 26 longitudinal studies [ 5 , 28 , 39 , 41 , 45 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ] with follow-up ranging from ~2 [ 39 , ...…”
Section: Resultsmentioning
confidence: 99%
“…Of the 52 studies included, 32 studies investigated the association between BP and WMLs volume, with all of them reporting a positive association ( n = 17,472, MWA = 57.8 years, women = 55.1%, hypertension = 35.4%). Seventeen cross-sectional [ 4 , 19 , 22 , 24 , 28 , 30 , 35 , 36 , 37 , 38 , 40 , 41 , 42 , 44 , 45 , 46 ] and 15 longitudinal studies [ 4 , 19 , 38 , 40 , 44 , 49 , 52 , 53 , 54 , 55 , 59 , 60 , 62 , 66 ] found that higher BP (SBP, n = 48%; DBP, n = 31.2%; PP, n = 8.3%; MAP, n = 12.5%) was associated with larger WMLs. The relationship reached significance in 20 (62.5%) studies (82.6% of participants; 55% longitudinal) ( Figure 4 ) [ 4 , 19 , 24 , 28 , 35 , 36 , 37 , 38 , 40 , 42 , 44 , 46 , 51 , 52 , 53 , 55 , 59 ...…”
Section: Resultsmentioning
confidence: 99%
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“…Although the association between cognitive performance and hypertension in younger adults has been documented (Suhr et al, 2004), the present findings provide novel insight to suggest BP may moderate cognitive performance differently in younger AA compared to CA. Given long-term exposure to higher BP from young to midadulthood accelerates cognitive decline in midlife (Mahinrad et al, 2020), our findings indicate that the racial disparity in higher BP-associated cognitive function may begin in early adulthood. While our results should be interpreted with caution as the significant interactions on cognitive outcomes did not survive FDR correction, the consistency of the magnitude and direction of these effects gives confidence that these findings are not merely spurious, and that accepting the null hypothesis would result in a Type II error.…”
Section: Discussionmentioning
confidence: 76%
“…1). Similar approach was also used to assess the deleterious effects of elevated cumulative exposure to blood pressure in early adulthood [8,9]. We determined diabetes based on any one of the following: self-report of hypoglycemic medications (measured at Y0, Y7, Y10, Y15, Y20 and Y25); fasting glucose levels ≥ 7.0 mmol/L or ≥ 126 mg/dL (measured at Y0, Y7, Y10, Y15, Y20 and Y25); 2-hour postload blood glucose ≥ 11.1 mmol/L or ≥ 200 mg/dL in 75 g oral glucose tolerance test (measured at Y10, Y20, Y25); or glycated hemoglobin ≥ 6.5% (measured at Y20 and Y25).…”
Section: Intensity Of Glycemic Exposure Assessment and Incident Diabetesmentioning
confidence: 99%