“…Fifty-two studies ( n = 343,794, weighted mean age (MWA) = 58.7 years, women = 53.2%) met the inclusion criteria presented in Supplementary Information; Table S2 . They included 33 cross-sectional [ 5 , 6 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ] and 26 longitudinal studies [ 5 , 28 , 39 , 41 , 45 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ] with follow-up ranging from ~2 [ 39 , ...…”