Cumulative dietary exposure to a selected group of pesticides of the triazole group in different European countries according to the EFSA guidance on probabilistic modelling

Boon, Polly; Donkersgoed, Gerda van; Christodoulou, Despo Louca; Crépet, Amélie; D’Addezio, Laura; Desvignes, Virginie; Ericsson, Bengt-Göran; Galimberti, Francesco; Ioannou–Kakouri, Eleni; Jensen, Bodil Hamborg; Řehůřková, Irena; Réty, J.; Ruprich, Jiří; Sand, Salomon; Stephenson, Claire; Strömberg, Anita; Turrini, Aida; Voet, Hilko van der; Ziegler, Popi; Hamey, Paul Y.; Klaveren, J.D. van

doi:10.1016/j.fct.2014.08.004

Cited by 48 publications

(18 citation statements)

References 14 publications

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“…As a result, MRA requires a considerable amount of assumptions. Their choice can have a large impact on the outcome and should be carefully documented and justified ( Boon et al, 2015 ; Kennedy et al, 2015 ). This is also the case for single chemical assessments; however, for MRA it is of particular importance since the uncertainties around single chemical assessments are compounded when combined risks are assessed.…”

Section: Main Concepts and Terminology In The Assessment Of Mixturesmentioning

confidence: 99%

Current EU research activities on combined exposure to multiple chemicals

Bopp

Barouki

Brack

et al. 2018

Environment International

191

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Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.

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Section: Main Concepts and Terminology In The Assessment Of Mixturesmentioning

confidence: 99%

Current EU research activities on combined exposure to multiple chemicals

Bopp

Barouki

Brack

et al. 2018

Environment International

191

View full text Add to dashboard Cite

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“…rivm.nl/Account/Login). This tool is designed to allow a cumulative assessment of exposure to multiple chemicals from multiple sources (67) and has been successfully applied for the assessment of acute and chronic exposure to a group of pesticides in a number of European countries (68) . Like the FACET tool, the ACROPOLIS tool is freely accessible.…”

Section: Recent Developments In Low-calorie Sweeteners Exposure Assesmentioning

confidence: 99%

The potential application of a biomarker approach for the investigation of low-calorie sweetener exposure

et al. 2016

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Low-calorie sweeteners (LCS) are commonly used as sugar substitutes in the diet to provide a desired sweet taste without increased energy intake. The number of LCS available on the market has increased considerably over the years and despite extensive evaluation of their safety prior to approval, debate continues around the effects of consumption on health. In Europe, Member States are obligated to monitor exposure to LCS and methods currently used tend to rely on self-reported dietary intake data alongside LCS concentrations in products. However, the acquisition of accurate data can be costly in terms of resources and time and are inherently imprecise. Although LCS are intensely sweet, they are chemically diverse and a limitation of many studies investigating the health effects of consumption is that they often fail to discern intakes of individual LCS. An approach which objectively assesses intakes of individual LCS would therefore allow robust investigations of their possible effects on health. Biomarker approaches have been utilised for the objective investigation of intakes of a range of dietary components and the feasibility of any such approach depends upon its validity as well as its applicability within the target population. This review aims to provide an overview of current understanding of LCS intake and explore the possibility of implementing a biomarker approach to enhance such understanding. Several commonly used LCS, once absorbed into the body, are excreted via the kidneys; therefore a urinary biomarker approach may be possible for the investigation of short-term exposure to these compounds.

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“…Stochasticity may be the option to provide this information by describing the parameters in the risk assessment algorithm that are variable and/or uncertain by probability distributions [ 11 ]. Probabilistic risk assessment in food safety is an established and applied research area in quantitative microbial risk assessment [ 13 ] and in exposure assessments to chemicals [ 14 , 15 ]. Probabilistic chemical risk assessments are still emerging, with methodologies developed such as the Integrated Probabilistic Risk Assessment(IPRA) [ 16 – 18 ] and tools such as the Aproximate Probabilistic-tool (APROBA) [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Probabilistic approach for assessing cancer risk due to benzo[a]pyrene in barbecued meat: Informing advice for population groups

et al. 2018

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BackgroundConsumption of meat prepared by barbecuing is associated with risk of cancer due to formation of carcinogenic compounds including benzo[a]pyrene (BaP). Assessment of a population’s risk of disease and people’s individual probability of disease given specific consumer attributes may direct food safety strategies to where impact on public health is largest. The aim of this study was to propose a model that estimates the risk of cancer caused by exposure to BaP from barbecued meat in Denmark, and to estimate the probability of developing cancer in subgroups of the population given different barbecuing frequencies.MethodsWe developed probabilistic models applying two dimensional Monte Carlo simulation to take into account the variation in exposure given age and sex and in the individuals’ sensitivity to develop cancer after exposure to BaP, and the uncertainty in the dose response model. We used the Danish dietary consumption survey, monitoring data of chemical concentrations, data on consumer behavior of frequency of barbecuing, and animal dose response data.FindingsWe estimated an average extra lifetime risk of cancer due to BaP from barbecued meat of 6.8 × 10−5 (95% uncertainty interval 2.6 × 10−7 − 7.0 × 10−4) in the Danish population. This corresponds to approximately one to 4,074 extra cancer cases over a lifetime, reflecting wide uncertainty. The impact per barbecuing event on the risk of cancer for men and women of low body weight was higher compared to higher bodyweight. However, the difference due to sex and bodyweight between subgroups are dwarfed by the uncertainty.InterpretationThis study proposes a model that can be applied to other substances and routes of exposure, and allows for deriving the change in risk following a specific change in behaviour. The presented methodology can serve as a valuable tool for risk management, allowing for the formulation of behaviour advice targeted to specific sub-groups in the population.

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Cumulative dietary exposure to a selected group of pesticides of the triazole group in different European countries according to the EFSA guidance on probabilistic modelling

Cited by 48 publications

References 14 publications

Current EU research activities on combined exposure to multiple chemicals

Current EU research activities on combined exposure to multiple chemicals

The potential application of a biomarker approach for the investigation of low-calorie sweetener exposure

Probabilistic approach for assessing cancer risk due to benzo[a]pyrene in barbecued meat: Informing advice for population groups

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