Cumulative Effect of Head Injuries on Nonmotor Outcomes in Parkinson’s Disease

Jones, Jacob D.; Timblin, Holly; Baxter, Fawn

doi:10.1176/appi.neuropsych.21100257

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…In non-PD populations, it has been recently demonstrated that prior head injury may be associated with the MBI-domains of affective dysregulation and impulse dyscontrol [141]. Cognitive complaints and more severe depressive symptoms have also been correlated with a higher number of prior head injuries in patients with PD [142].Neuroinflammation, abnormal protein accumulation including beta-amyloid, tau and alpha-synuclein, as well as metabolic dysregulation have been proposed as potential underlying mechanisms linking traumatic brain injury and PD [143], suggesting that these mechanisms might also play a role in PD-related MBI.…”

Section: Future Perspectivesmentioning

confidence: 99%

Mild Behavioral Impairment in Parkinson’s Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects

Angelopoulou,

Bougea,

Hatzimanolis

et al. 2024

Medicina

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Neuropsychiatric symptoms (NPS), including depression, anxiety, apathy, visual hallucinations, and impulse control disorders, are very common during the course of Parkinson’s disease (PD), occurring even at the prodromal and premotor stages. Mild behavioral impairment (MBI) represents a recently described neurobehavioral syndrome, characterized by the emergence of persistent and impactful NPS in later life, reflecting arisk of dementia. Accumulating evidence suggests that MBI is highly prevalent in non-demented patients with PD, also being associated with an advanced disease stage, more severe motor deficits, as well as global and multiple-domain cognitive impairment. Neuroimaging studies have revealed that MBI in patients with PD may be related todistinct patterns of brain atrophy, altered neuronal connectivity, and distribution of dopamine transporter (DAT) depletion, shedding more light on its pathophysiological background. Genetic studies in PD patients have also shown that specific single-nucleotide polymorphisms (SNPs) may be associated with MBI, paving the way for future research in this field. In this review, we summarize and critically discuss the emerging evidence on the frequency, associated clinical and genetic factors, as well as neuroanatomical and neurophysiological correlates of MBI in PD, aiming to elucidate the underlying pathophysiology and its potential role as an early “marker” of cognitive decline, particularly in this population. In addition, we aim to identify research gaps, and propose novel relative areas of interest that could aid in our better understanding of the relationship of this newly defined diagnostic entity with PD.

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Section: Future Perspectivesmentioning

confidence: 99%

Mild Behavioral Impairment in Parkinson’s Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects

Angelopoulou,

Bougea,

Hatzimanolis

et al. 2024

Medicina

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Parkinson's Disease Progression and Exposure to Contaminated Water at Camp Lejeune

Goldman,

Weaver,

Gonzalez

et al. 2024

Movement Disorders

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BackgroundWe recently reported an increased risk of Parkinson's disease (PD) in service members who resided at Marine Base Camp Lejeune, North Carolina, when water supplies were contaminated with trichloroethylene and other volatile organic compounds (VOCs). Prior studies suggest that environmental exposures may affect PD phenotype or progression, but this has not been reported for VOCs.ObjectiveThe objective of this study was to test whether PD progression is faster in individuals exposed to VOCs in water at Camp Lejeune.MethodsA cohort of 172,128 marines residing at Camp Lejeune between 1975 and 1985 was previously assembled. We identified individuals with PD in Veterans Health Administration and Medicare databases between 2000 and 2021. Using estimates derived by the US Agency for Toxic Substances and Disease Registry, we classified individuals as exposed or unexposed to VOCs in residential water. We used Kaplan–Meier and Cox regression models to test differences between exposed and unexposed groups in the time from PD diagnosis until psychosis, fracture, fall, or death.ResultsAmong 270 persons with PD, 177 (65.6%) were exposed to VOCs in residential water. Median cumulative exposure was 4970 μg/L‐months, >50‐fold the permissible level. Time until psychosis, fracture, and fall were all shorter in the exposed group, with adjusted hazard ratios (HRs) exceeding 2: psychosis HR, 2.19 (95% confidence interval [CI]: 0.99–4.83); fracture HR, 2.44 (95% CI: 0.91–6.55); and fall HR, 2.64 (95% CI: 0.97–7.21). A significant dose response was observed for time to fall (P trend, 0.032). No differences were observed for time until death.ConclusionsPD progression may be faster in persons exposed to trichloroethylene and other VOCs in water decades earlier. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

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Cumulative Effect of Head Injuries on Nonmotor Outcomes in Parkinson’s Disease

Cited by 2 publications

References 35 publications

Mild Behavioral Impairment in Parkinson’s Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects

Mild Behavioral Impairment in Parkinson’s Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects

Parkinson's Disease Progression and Exposure to Contaminated Water at Camp Lejeune

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