Cumulative exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan

Oya, Naoko; Ito, Yuki; Ebara, Takeshi; Kato, Sayaka; Ueyama, Jun; Aoi, Arisa; Nomasa, Karin; Sato, Hirotoshi; Matsuki, Taro; Sugiura‐Ogasawara, Mayumi; Saitoh, Shinji; Kamijima, Michihiro

doi:10.1016/j.scitotenv.2020.141630

Cited by 32 publications

(30 citation statements)

References 32 publications

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“…In this connection, very recent human biomonitoring study confirmed the DNA damage and immunological changes in farm workers exposed to pesticides (Ramos et al, 2021). Likewise, a large number of young children in Japan aged between 16 and 23 months showed the urinary presence of neonicotinoids (Oya et al, 2021). In spite of these facts, pesticidal toxicity in the ECs and their effects on angiogenesis is sparse.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Saquib

Siddiqui

Ansari

et al. 2021

J of Applied Toxicology

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Pesticides have adverse effects on the cellular functionality, which may trigger myriad of health consequences. However, pesticides‐mediated toxicity in the endothelial cells (ECs) is still elusive. Hence, in this study, we have used human umbilical vein endothelial cells (HUVECs) as a model to quantify the cytotoxicity and genotoxicity of four pesticides (methomyl, carbaryl, metalaxyl, and pendimethalin). In the MTT assay, HUVECs exposed to methomyl, carbaryl, metalaxyl, and pendimethalin demonstrated significant proliferation inhibition only at higher concentrations (500 and 1000 μM). Likewise, neutral red uptake (NRU) assay also showed proliferation inhibition of HUVECs at 500 and 1000 μM by the four pesticides, confirming lysosomal fragility. HUVECs exposed to the four pesticides significantly increased the level of intracellular reactive oxygen species (ROS). Comet assay and flow cytometric data exhibited DNA damage and apoptotic cell death in HUVECs after 24 h of exposure with methomyl, metalaxyl, carbaryl, and pendimethalin. This is a first study on HUVECs signifying the cytotoxic–genotoxic and apoptotic potential of carbamate insecticides (methomyl and carbaryl), fungicide (metalaxyl), and herbicide (pendimethalin). Overall, these pesticides may affect ECs functions and angiogenesis; nonetheless, mechanistic studies are warranted from the perspective of vascular biology using in vivo test models.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Saquib

Siddiqui

Ansari

et al. 2021

J of Applied Toxicology

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“…Among children aged ≤3 years, a subset of patients treated for CH are later determined not to have permanent CH at the end of the treatment. In the present study, we used birth cohort data that included CH history and test results using dried blood spot samples on chromatography paper [19]. We aimed to quantify the associations between varied routes of mother's iodine exposure and child hypothyroidism incidence from birth to 1 year of age.…”

mentioning

confidence: 99%

Mother’s iodine exposure and infants’ hypothyroidism: the Japan Environment and Children’s Study (JECS)

et al. 2022

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In this study, we aimed to determine the association of neonatal/post-neonatal hypothyroidism with mother's iodine exposure, especially povidone iodine disinfection, and hysterosalpingography. Participants were mother-child pairs in a Japanese birth cohort (n = 100,286). Risk factors of hypothyroidism were supplement intake, seaweed intake, other daily iodine intake, povidone iodine disinfection at delivery, and maternal history of hysterosalpingography, thyroid disease (Graves' disease and Hashimoto's thyroiditis), and medication (thiamazole and levothyroxine). Congenital hypothyroidism (CH) at age 1 year was assessed using a questionnaire. Transient hypothyroidism was defined as elevated thyroid stimulating hormone level at birth and absence of CH at age 1 year. The incidence of CH at age 1 year per 100 children was 1.1 for those born at 22-30 weeks' gestation, 0.17 following povidone iodine disinfection, and 0.07, 0.95, 0.81, 1.17, and 1.15 with a maternal history of hysterosalpingography, Graves' disease, Hashimoto's thyroiditis, thiamazole use, and levothyroxine use, respectively. Odds ratios (95% confidence intervals) of CH at age 1 year for povidone iodine disinfection, hysterosalpingography history, maternal Graves' disease, and maternal Hashimoto's thyroiditis were 1.13 (0.71-1.79), 0.47 (0.07-3.36), 7.06 (3.70-13.5), and 5.93 (2.90-12.1), respectively. For transient hypothyroidism for povidone iodine disinfection and hysterosalpingography history, these values were 1.99 (1.51-2.62) and 0.63 (0.20-1.96), respectively. Maternal thyroid disease greatly increased neonatal/post-neonatal hypothyroidism risk. Povidone iodine disinfection may increase transient hypothyroidism risk but not the risk at 1 year of age. Hysterosalpingography does not increase hypothyroidism risk from birth to age 1 year.

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“…This strongly confirms that dinotefuran dominates in the domestic applications of NEOs in Japan. The median concentration of all the target NEOs recorded in the green tea leaves were higher than the urinary NEO concentrations reported in Japanese [ [24] , [25] , [26] ] and other populations in Ghana [ 27 ], China [ 28 , 29 ] and USA [ 30 ]. Apart from imidacloprid and nitenpyram, the maximum concentrations of all the NEO parent compounds (acetamiprid, clothianidin, dinotefuran, thiacloprid and thiamethoxam) detected in the current green tea samples were higher than their respective urinary concentrations reported in urine of Japanese, Ghanaians, Chinese and Americans [ [24] , [25] , [26] , [27] , [28] , [29] , [30] ], as shown in Supplementary Data, Table S6.…”

Section: Resultsmentioning

confidence: 60%

“…Supplementary Data, Table S6 shows comparisons between concentrations of 8 NEOs detected in the overall green tea leave samples (current study, n = 103) and the urinary concentrations of the target NEOs in Japanese and/or other human populations across the world. From the data, dinotefuran had dominant detection rates both in green tea leaves and in Japanese urine [ [24] , [25] , [26] ]. This strongly confirms that dinotefuran dominates in the domestic applications of NEOs in Japan.…”

Section: Resultsmentioning

confidence: 99%

Neonicotinoid residues in commercial Japanese tea leaves produced by organic and conventional farming methods

et al. 2021

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Cumulative exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan

Cited by 32 publications

References 32 publications

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Mother’s iodine exposure and infants’ hypothyroidism: the Japan Environment and Children’s Study (JECS)

Neonicotinoid residues in commercial Japanese tea leaves produced by organic and conventional farming methods

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