Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation

Arslan, Murat; Bocca, Silvina; Arslan, Ebru; Duran, Eyup Hakan; Stadtmauer, Laurel; Oehninger, Sergio

doi:10.1007/s10815-006-9101-x

Cited by 52 publications

(40 citation statements)

References 40 publications

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“…[24][25][26] Nevertheless, no relationship was found in this study between endometrial thickness and maximum estradiol levels and β-hCG value.…”

Section: Discussioncontrasting

confidence: 64%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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-hCG (beta-human chorionic gonadotrophin) is a pregnancy-associated molecule produced by implanted blastocysts and trophoblastic cells. β-hCG as one of the earliest embryonal signals may be a major regulator in the paracrine embryo-endometrial communication.1,2 β-hCG measurement in serum is a method used routinely for pregnancy test after the IVF (invitro fertilization) procedure.3 Serial measurements of β-hCG is a marker which is also used for distinguishing pregnancies running their course from ectopic pregnancy or spontaneous pregnancy losses in early pregnancy. [4][5][6] In increasing number of recent studies, it has become a current issue that β-hCG levels in early A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study is to investigate the parameters of female, male and cycles that could affect post-ART (assisted reproductive techniques)-pregnancy initial beta hCG value. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this retrospective study, data of 3056 individuals who had become pregnant with IVF/ICSI at a private IVF center and between 2006 and 2016 and whose pregnancies continued for over 12 weeks were evaluated. Initial beta-hCG values of these pregnancies were compared with parameters of mothers, fathers and cycles. R Re es su ul lt ts s: : It was seen in this study that there is a negative correlation between the initial beta-hCG values of pregnancies achieved by assisted reproductive techniques and mothers BMI values and a positive correlation between those beta-hCG values and the embryo transfer day. C Co on nc cl lu us si io on n: : The data obtained in the study need to be supported with larger series in the future. It is also thought that these data may contribute to the literature which tries to achieve a β -hCG cut-off value in the determination of pregnancy outcome. Ya zış ma Ad re si/Cor res pon den ce:

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“…[24][25][26] Nevertheless, no relationship was found in this study between endometrial thickness and maximum estradiol levels and β-hCG value.…”

Section: Discussioncontrasting

confidence: 64%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

View full text Add to dashboard Cite

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“…Scientific, Perkasie, PA) using 1.5 mol/L 1,2 propanediol as the cryoprotectant with the addition of sucrose (0.2 mol/L) [3,13,14,18]. Specimens were kept in cryovials containing 0.3 mL of cryoprotective medium and maintained at −196°C under liquid nitrogen in storage tanks (35 VHC liquid nitrogen storage tank; Taylor-Warton Cryogenic Equipment, Indianapolis, IN).…”

Section: Methodsmentioning

confidence: 99%

“…An individual embryo quality score was calculated by multiplying the number of blastomeres times the morphology grade. A cumulative embryo score per transfer was calculated by adding the scores of all individual embryos and was then divided by the number of embryos to obtain a "mean score of transferred embryos" (MSTE) [13].…”

Section: Methodsmentioning

confidence: 99%

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Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement

Bocca

Real

Lynch

et al. 2015

J Assist Reprod Genet

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Purpose To investigate the impact of late follicular phase serum estradiol (E 2 ) levels on implantation and pregnancy outcomes of cleavage stage cryopreserved/thawed embryos transferred in programmed cycles with exogenous hormonal replacement. Methods Retrospective cohort analysis of IVF patients with transfer of cryopreserved-thawed day-3 embryos in E 2 and progesterone (P4) supplemented cycles (n=208 cycles). Main outcome measures: implantation and pregnancy rates according to late follicular phase serum E 2 levels and early secretory phase E 2 /P4 ratios. Results Logistic regression performed for embryo implantation and for pregnancy outcome in relation to E 2 (day 15), P4 (day 15 and 16), before (crude analysis) and after adjustment (adjusted analysis) for baseline characteristics (including age, BMI, serum basal cycle day 3 FSH levels, embryo quality, endometrial lining thickness) showed no significant association. Similarly, ROC analysis showed no impact of cycle day 16 E 2 /P4 ratio. Conclusions Neither late follicular phase serum E 2 nor the early E 2 /P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.

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“…The ovary was removed from the endobag (10 min maximum ischemia time) and placed in a large Petri dish containing warm Quinn's Advantage Medium with HEPES supplemented with heparin. The oocyte retrieval was performed with the standard equipment for transvaginal oocyte aspiration for IVF [3]. The follicular fluid was immediately given in tubes to the embryologist who proceeded to identification of the cumulus-corona complexes under a dissecting microscope in the same operating room.…”

mentioning

confidence: 99%

Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor

Bocca

Dedmond²,

Jones

et al. 2011

J Assist Reprod Genet

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Purpose To report the successful extracorporeal recovery of mature oocytes after laparoscopic oophorectomy following ovarian hyperstimulation for the purpose of fertility preservation in a patient with recurrent serous borderline ovarian tumor. Methods A 25-year-old nulligravida woman presented with recurrence of a borderline serous adenocarcinoma in the right ovary after been treated conservatively with left oophorectomy for the same. Result(s) The patient underwent ovarian stimulation followed by a laparoscopic oophorectomy and ex-vivo retrieval of oocytes. Twenty two oocytes were recovered: fourteen metaphases II, two metaphases I, five prophases I and one degenerate. Conclusion(s) Mature oocytes were successfully retrieved ex-vivo from the hyperstimulated ovary recovered via laparoscopy. The procedure can be performed in a quick manner, with standard equipment, without damaging the ovary, the follicles or the oocytes, and without the risk of cancer cell spillage associated with the standard transvaginal oocyte retrieval if there is concern of ovarian surface/peritoneal metastatic disease.

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Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation

Abstract: High cumulative E(2) exposure during the follicular phase of IVF cycles has detrimental effects on implantation.

Cited by 52 publications

References 40 publications

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement

Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor

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