Cumulative exposure to organic pollutants of French children assessed by hair analysis

Iglesias-González, Alba; Hardy, E.-M.; Appenzeller, Brice

doi:10.1016/j.envint.2019.105332

Cited by 68 publications

(21 citation statements)

References 122 publications

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“…CPF is recognized as a neurotoxic agent due to its inhibitory effect on various cholinesterase (ChE) enzymes at the central nervous (CNS) and systemic level [ 21 ]. High levels of pesticide residues have been found in several human cohorts [ 22 , 23 , 24 , 25 , 26 ]. According to the United States Environmental Protection Agency (EPA), the no-observed-adverse-effect level (NOAEL) of CPF for acute dietary exposure for the inhibition of red blood cell cholinesterase is 0.5 mg/kg/day [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring

Djekkoun

Dépeint

Guibourdenche

et al. 2022

Toxics

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An increasing burden of evidence is pointing toward pesticides as risk factors for chronic disorders such as obesity and type 2 diabetes, leading to metabolic syndrome. Our objective was to assess the impact of chlorpyrifos (CPF) on metabolic and bacteriologic markers. Female rats were exposed before and during gestation and during lactation to CPF (1 mg/kg/day). Outcomes such as weight, glucose and lipid profiles, as well as disturbances in selected gut bacterial levels, were measured in both the dams (at the end of the lactation period) and in their female offspring at early adulthood (60 days of age). The results show that the weight of CPF dams were lower compared to the other groups, accompanied by an imbalance in blood glucose and lipid markers, and selected gut bacteria. Intra-uterine growth retardation, as well as metabolic disturbances and perturbation of selected gut bacteria, were also observed in their offspring, indicating both a direct effect on the dams and an indirect effect of CPF on the female offspring. Co-treatment with inulin (a prebiotic) prevented some of the outcomes of the pesticide. Further investigations could help better understand if those perturbations mimic or potentiate nutritional risk factors for metabolic syndrome through high fat diet.

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Section: Introductionmentioning

confidence: 99%

Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring

Djekkoun

Dépeint

Guibourdenche

et al. 2022

Toxics

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“…Fipronil can be degraded into metabolites in the environment, mainly including fipronil desulfinyl, fipronil sulfone, and fipronil sulfide . Fipronil and its metabolites have been found in environmental samples, such as surface water, drinking water, indoor and outdoor dust, − and food samples, − including vegetables, dietary samples, eggs, milk, teas, etc., as well as biological samples, ,− such as urine, serum, and hair. All of these indicate that fipronil is ubiquitous in the environment.…”

Section: Introductionmentioning

confidence: 99%

Human Exposure of Fipronil Insecticide and the Associated Health Risk

Chen

Zhao

et al. 2021

J. Agric. Food Chem.

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Fipronil, as an emerging phenylpyrazole insecticide, is ubiquitous in the environment and food due to its broad spectrum and persistent characteristics, but the research on pathways of human exposure to fipronil and the associated health risk is relatively unclear. In this regard, we summarize potential human exposures to fipronil through ingestion and inhalation, as well as results of human biomonitoring studies. This scientific information will contribute to future assessment of fipronil exposure and subsequent characterization of human health risks. Additionally, this Perspective highlights the lack of epidemiological studies and total diet studies for the general population on fipronil.

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“…Exposure of pregnant women and children to endocrine active pesticides-as were detected in our grass samples-and/or their metabolites have been described in several publications. For example, di-ethyl phosphate and 3,5,6-trichloro-2-pyridinol, both metabolites of chlorpyrifos and chlorpyrifos-methyl, were detected in urine samples from children [73] and hair samples from pregnant women [74,75], as well as cypermethrin, cyprodinil, difenoconazole, imidacloprid, oxadiazon, penconazole, propiconazole, pyraclostrobin, pyrimethanil, tebuconazole, tetraconazole, thiacloprid and zoxamid [74,76]. Many of the EDCs are fungicides-in this study 75%-which is also the most prevalent group of detected residues in the current sites.…”

Section: Potential Impact Of Pesticide Residues On Human Healthmentioning

confidence: 99%

Year-round pesticide contamination of public sites near intensively managed agricultural areas in South Tyrol

Linhart¹,

Panzacchi

Belpoggi

et al. 2021

Environ Sci Eur

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Background In a previous study, we found that 45% of public playgrounds near intensively managed agricultural areas were contaminated with mainly endocrine active pesticide residues in spring. Here, we investigated potential contamination over the course of a year. Methods Residue data were analyzed from 96 grass samples collected in spring, summer, autumn, and winter by the South Tyrolean Medical Service in 19 public playgrounds, four schoolyards, and one marketplace located within intensively managed agricultural landscapes. Samples were analyzed for 281 substances using gas-chromatography and mass-spectrometry. Results A total of 32 pesticide residues and one preservative agent were found. Almost all of the sites (96%) were contaminated with at least one residue during the year; in 79% of the sites, more than one residue was found. Among the detected residues, 76% are classified as endocrine active substances, with the highest concentrations of the insecticide chlorpyrifos-methyl (0.71 mg kg−1), the herbicide oxadiazon (0.64 mg kg−1), and the fungicides captan (0.46 mg kg−1) and fluazinam (0.23 mg kg−1). The number of residues, their concentrations, and the proportion of contaminated sites varied across seasons (p < 0.001). Twenty-five residues were found in 83% of the sites in spring (median concentration 0.240 mg kg−1), nine in 79% of the sites in summer (0.092 mg kg−1), three in 50% of the sites in autumn (0.076 mg kg−1), and four in 17% of the sites in winter (0.155 mg kg−1). Playgrounds already examined in 2017 in the previous study, were more often contaminated with multiple pesticide residues in 2018 (p = 0.045). Conclusion This study confirms previous findings of widespread pesticide contamination of public sites within intensively managed agricultural areas. Moreover, pesticide residues were also found in periods with little or no pesticide application in the field (autumn and winter). It is worrisome that many of the detected residues are endocrine active substances and that some of them (thiacloprid, bupirimate, captan, folpet) are “suspected human carcinogens”, according to EU authorities. Thus, we call for more effective controls of pesticide applications to minimize pesticide drift into public places.

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Cumulative exposure to organic pollutants of French children assessed by hair analysis

Cited by 68 publications

References 122 publications

Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring

Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring

Human Exposure of Fipronil Insecticide and the Associated Health Risk

Year-round pesticide contamination of public sites near intensively managed agricultural areas in South Tyrol

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