2020
DOI: 10.1186/s12199-020-00864-7
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Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

Abstract: Background Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. We hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity. We examined the relationship between immunisation with different vaccine types and later allergic disease development. Methods We obtained information regarding vaccinations and all… Show more

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Cited by 13 publications
(10 citation statements)
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“…This was a nationwide, multicenter, prospective general birth cohort study: the Japan Environment and Children’s Study (JECS) [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. A general population of 103,060 pregnancies/97,413 mothers and 49,279 fathers was enrolled in the JECS from January 2011 to March 2014.…”
Section: Methodsmentioning
confidence: 99%
“…This was a nationwide, multicenter, prospective general birth cohort study: the Japan Environment and Children’s Study (JECS) [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. A general population of 103,060 pregnancies/97,413 mothers and 49,279 fathers was enrolled in the JECS from January 2011 to March 2014.…”
Section: Methodsmentioning
confidence: 99%
“…This study was registered to the UMIN Clinical Trials Registry (number: UMIN000030786). Details of the protocol and baseline profiles of participants in the JECS have been described elsewhere [24][25][26]. The JECS protocol was reviewed and approved by the Institutional Review Board on Epidemiological Studies of the Ministry of the Environment, and by the ethics committees of all participating institutions.…”
Section: Study Design and Participantsmentioning
confidence: 99%
“…Furthermore, misclassification of dietary intake, which could lead to underestimation, may have occurred as the FFQ was self-reported. Third, although previous studies have used asthma, atopic dermatitis, and food allergy based on the doctor’s diagnosis as outcome variables [ 47 , 48 ], these have not been validated. However, we complementally used those variables in addition to wheeze and eczema using a questionnaire because the assessment of allergic outcomes in offspring at one year of age is challenging.…”
Section: Discussionmentioning
confidence: 99%