Cumulative incidence of and risk factors for herpes zoster among patients with diabetes mellitus: Results from a 10-year nested case-control study

Chuanchaiyakul, Nalinee; Thongtang, Nuntakorn; Rattanaumpawan, Pinyo

doi:10.1016/j.jdiacomp.2022.108168

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…The authors also suggested the risk of diabetic complications be stratified on the basis of NAFLD [ 21 ]. After a 10-year nested case–control study of 1428 patients, Chuanchaiyakul et al reported that the IR of HZ was 3.96 per 1,000 person-years [ 22 ]. Patients with DM were at a higher risk of HZ than were the patients without DM.…”

Section: Discussionmentioning

confidence: 99%

Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease

Yu,

Chen,

Cheng

et al. 2023

Eur J Med Res

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Background Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in affected individuals. In this study, we investigated whether FLD is associated with an elevated risk of HZ. Methods For this study, we utilized data from the National Health Insurance Research Database, patients with FLD from 2000 to 2017 were observed (follow-up until 2018). Patients were considered to have FLD if they had at least two outpatient visits or at least one admission record with a diagnostic code of FLD. Patients with FLD were matched 1:1 by age, sex, comorbidities, and index year with control patients. Additionally, the FLD was further categorized into non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) groups. Multivariable Cox proportional hazards model was used to calculate the incidence rate and adjusted hazard ratio (aHR) of HZ for FLD and AFLD and for various age groups, sex and comorbidities. Cumulative incidence curve for HZ was plotted through the Kaplan–Meier method, and p-value was calculated using the log-rank test. Results After 1:1 propensity-score matching, each cohort comprised 62,418 patients. The FLD cohort was further divided into NAFLD and AFLD groups, which respectively comprised 55,709 and 6709 patients. The FLD cohort had a risk of HZ significantly higher than that of the control cohort (aHR = 1.06; p < 0.001). Additionally, the NAFLD group exhibited a significantly higher risk of HZ than did the AFLD group (aHR = 1.22; p < 0.001). Among patients without any comorbidities, those with FLD had a higher risk of HZ than did those without FLD (aHR = 1.14; p < 0.001). Conclusion Patients with FLD are at an increased risk of HZ development. Additionally, NAFLD is associated with a higher risk of HZ than AFLD. Therefore, patients with NAFLD should be informed of their increased risk of HZ.

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Section: Discussionmentioning

confidence: 99%

Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease

Yu,

Chen,

Cheng

et al. 2023

Eur J Med Res

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“…In a meta-analysis examining risk factors, it was stated that autoimmune diseases (RA and SLE), inflammatory bowel disease, DM, chronic kidney disease, chronic obstructive pulmonary disease, depression, and asthma posed an increased risk for HZ (12). In a study conducted in Thailand in 2022, the incidence of HZ was 3.96/person-year in patients with DM, and HT was revealed as an independent risk factor (22). In another study investigating the incidence of HZ in patients with RA, risk factors for HZ were HT and dyslipidemia independent of antirheumatic therapy, gender, and age (23).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Demographic and Clinical Characteristics of Patients Diagnosed with Herpes Zoster

Saadet

Hasanbeyzade

2023

Genel Tıp Dergisi

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Background: Herpes zoster is a disease that is more frequently seen in people aged over 50 years and negatively affects the quality of life due to the development of post-herpetic neuralgia. This study aimed to investigate the demographic and clinical characteristics of patients diagnosed with herpes zoster. Methods: In this cross-sectional study, the data of patients who were followed up with a diagnosis of herpes zoster at the dermatology department between 2013 and 2020 were retrospectively examined. Results: Of 440 patients, 252 (57.3%) were female and 188 (42.7%) were male. The mean age was 48.9±18 (4-94) years. The most common localization was the thoracic region at a rate of 35.5% and the lumbar region at a rate of 21.4%. Disseminated and ophthalmic zoster were more common in elderly patients (p

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“…Herpes zoster is an infection that occurs after reactivation of the varicella-zoster virus and is most common in people older than 50 years who have age-related fading of the immune function and concomitant comorbidities[ 31 ]. Herpes zoster is more prevalent among people with diabetes mellitus[ 32 ].…”

Section: Routine Vaccines For Diabetes Patientsmentioning

confidence: 99%

Effectiveness and safety of COVID-19 vaccines in patients with diabetes as a factor for vaccine hesitancy

Vasilev¹,

Kabakchieva²,

Miteva³

et al. 2022

WJD

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Diabetes mellitus is one of the most common comorbid conditions encountered in patients with severe acute respiratory syndrome coronavirus 2 infection accompanied by significantly increased mortality, prolonged hospital stay, and requirement of invasive mechanical ventilation. This review aims to present the effectiveness and safety profile of available coronavirus disease 2019 (COVID-19) vaccines in people with diabetes as a potential cause of hesitancy for vaccination. Data from published research proves a robust immune response following immunization for COVID-19 in diabetic patients with substantial production of virus-neutralizing antibodies; however, the observed immune response was unequivocally weaker than that in individuals without diabetes. This observation was further enhanced by the findings that worse glycemic control was associated with more suppressed antibody production. In contrast, individuals with optimal glycemic control performed similarly to healthy controls. In addition to the need for strict glucose monitoring and adequate diabetes treatment, those findings reinforce the concept of diabetes-induced secondary immune deficiency and necessitate the application of booster doses to diabetic patients with priority. Nevertheless, after vaccination, reported adverse events were not different from those in the general population. No increase in severe adverse events was documented. While single case reports detected transient increases in blood glucose post-vaccination, more extensive trials could not replicate such a relationship.

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Cumulative incidence of and risk factors for herpes zoster among patients with diabetes mellitus: Results from a 10-year nested case-control study

Cited by 5 publications

References 17 publications

Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease

Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease

Evaluation of the Demographic and Clinical Characteristics of Patients Diagnosed with Herpes Zoster

Effectiveness and safety of COVID-19 vaccines in patients with diabetes as a factor for vaccine hesitancy

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